Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting

Farrag Nourihan S.; El-Sabagh Hanan A.; Al-mahallawi Abdulaziz M.; Amin Abeer M.; AbdEl-Bary Ahmed; Mamdouh Wael

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Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting

机译：核心 - 壳银/聚合物纳米粒子核靶向核靶向核靶标的比较研究

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A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using I-125 isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using gamma-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time. The reported highly efficient method provides new radiolabeled Ag-based NPs as tumor-specific agents for both diagnostic and therapeutic applications. (C) 2017 Published by Elsevier B.V.

机译：已经使用I-125同位素进行三种Ag NPS的放射性标记的简单且快速的方法，其具有高标记产率，> 90％而不会干扰光学性质。研究了影响标记产量的所有因素。为了使用γ射线监测放射性标记的Ag nps的体内组织吸收，静脉内注射基于γ射线的Ag基于标记产率的基于Ag的放射性钠-NP。初步生物分布研究表明，这种新的放射性碘-NP在很长一段时间内具有高亲和力才能在肿瘤部位定位。报告的高效方法提供了新的放射性标记的Ag基于诊断和治疗应用的肿瘤特异性剂。（c）2017年由Elsevier B.V发布。

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《International Journal of Pharmaceutics》 |2017年第2期|共11页
作者
Farrag Nourihan S.; El-Sabagh Hanan A.; Al-mahallawi Abdulaziz M.; Amin Abeer M.; AbdEl-Bary Ahmed; Mamdouh Wael;
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作者单位

Atom Energy Author Hot Labs Ctr Labeled Cpds Dept Cairo Egypt;

Atom Energy Author Hot Labs Ctr Labeled Cpds Dept Cairo Egypt;

Cairo Univ Dept Pharmaceut &

Ind Pharm Fac Pharm Cairo Egypt;

Atom Energy Author Hot Labs Ctr Labeled Cpds Dept Cairo Egypt;

Cairo Univ Dept Pharmaceut &

Ind Pharm Fac Pharm Cairo Egypt;

Amer Univ Cairo Sch Sci &

Engn Dept Chem Cairo 11835 Egypt;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Silver nanoparticles (Ag NPs); Doxorubicin (DOX); Polyvinylpyrolidone (PVP); Radioiodination; Biodistribution; Tumor localization;

机译：银纳米粒子（Ag NPS）;多柔比星（DOX）;聚乙烯吡咯烷酮（PVP）;放射性碘化;生物分布;肿瘤定位;

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1. Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting [J] . Farrag Nourihan S., El-Sabagh Hanan A., Al-mahallawi Abdulaziz M., International Journal of Pharmaceutics . 2017,第1a2期

机译：核心 - 壳银/聚合物纳米粒子核靶向核靶向核靶标的比较研究
2. Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies [J] . Jeferson Freitas Toregeani, Shijie Luan, Feng Chen, Advanced Science . 2016,第11期

机译：体内工程学锆89放射性标记的自毁介孔二氧化硅纳米结构的体内生物分布和肿瘤靶向研究
3. Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP(A (R)) Peptides) Conjugated with Different Fluorescent Dyes [J] . Adochite Ramona-Cosmina, Moshnikova Anna, Golijanin Jovana, Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2016,第5期

机译：不同荧光染料与pH（低）插入肽（pHLIP（A（R））肽）的肿瘤靶向和生物分布的比较研究
4. Radiolabeling and Biodistribution of Elastin-Like Polypeptide in Response to TumorHyperthermia [C] . Wenge Liu, Matthew R. Dreher, Darin Y. Furgeson, Annual meeting exposition of the Controlled Release Society . 2005

机译：弹性蛋白样多肽对肿瘤热疗的放射性标记和生物分布
5. Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy. [D] . Park, Bora. 2014

机译：第一部分：针对FtsZ作为抗结核药的新型2,5,6-三取代苯并咪唑的设计，合成和生物学评估。第二部分新型基于紫杉醇的药物结合物和治疗诊断剂在肿瘤靶向化疗中的应用。
6. Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies [O] . Shreya Goel, Feng Chen, Shijie Luan, 2016

机译：本质上工程化锆89放射性标记的自毁中孔二氧化硅纳米结构用于体内生物分布和肿瘤靶向研究
7. Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies [O] . Shreya Goel, Feng Chen, Shijie Luan, 2016

机译：工程本质上锆 - 89放射性标记的自毁介析介孔二氧化硅纳米结构，用于体内生物分布和肿瘤靶向研究

Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting

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