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首页> 外文期刊>International Journal of Pharmaceutics >Applicability of low-melting-point microcrystalline wax to develop temperature-sensitive formulations
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Applicability of low-melting-point microcrystalline wax to develop temperature-sensitive formulations

机译：低熔点微晶蜡的适用性发展温度敏感配方

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Graphical abstract Display Omitted Abstract Low-melting-point substances are widely used to develop temperature-sensitive formulations. In this study, we focused on microcrystalline wax (MCW) as a low-melting-point substance. We evaluated the drug release behavior of wax matrix (WM) particles using various MCW under various temperature conditions. WM particles containing acetaminophen were prepared using a spray congealing technique. In the dissolution test at 37°C, WM particles containing low-melting-point MCWs whose melting was starting at approx. 40°C (Hi-Mic-1045 or 1070) released the drug initially followed by the release of only a small amount. On the other hand, in the dissolution test at 20 and 25°C for WM particles containing Hi-Mic-1045 and at 20, 25, and 30°C for that containing Hi-Mic-1070, both WM particles showed faster drug release than at 37°C. The characteristic drug release suppression of WM particles containing low-melting-point MCWs at 37°C was thought attributable to MCW melting, as evidenced by differential scanning calorimetry analysis and powder X-ray diffraction analysis. Taken together, low-melting-point MCWs may be applicable to develop implantable temperature-sensitive formulations that drug release is accelerated by cooling at administered site. ]]>
机译：图形摘要显示屏省略了抽象的低熔点物质广泛用于开发温度敏感的配方。在这项研究中，我们将微晶蜡（MCW）聚焦为低熔点物质。在各种温度条件下，我们使用各种MCW评估了蜡基质（WM）颗粒的药物释放行为。使用喷雾凝固技术制备含有乙酰氨基酚的WM颗粒。在37℃的溶出试验中，含有含有低熔点MCW的WM颗粒，其熔化开始于约。 40°C（Hi-MIC-1045或1070）最初释放出药物，然后仅释放少量。另一方面，在20和25℃的溶解试验中，对于含有Hi-MIC-1070的Hi-MIC-1045和20,25和30℃的WM颗粒，两种WM颗粒均显示出更快的药物释放比在37°C。在37℃下含有低熔点MCWs的WM颗粒的特征药物释放抑制因MCW熔化而被认为是差异扫描量热法分析和粉末X射线衍射分析所证明的。占用在一起，低熔点MCW可能适用于开发可植入的温度敏感制剂，其通过在施用位点冷却来加速药物释放。 ]]>

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