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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Postpolymerization modification of a hydroxy monolith precursor. Part III. Activation of poly(hydroxyethyl methacrylate‐co‐pentaerythritol triacrylate) monolith with epoxy functionalities followed by bonding of glycerol, polyamines, and hydroxypropyl‐β‐cyclodextrin for hydrophilic interaction and chiral capillary electrochromatography
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Postpolymerization modification of a hydroxy monolith precursor. Part III. Activation of poly(hydroxyethyl methacrylate‐co‐pentaerythritol triacrylate) monolith with epoxy functionalities followed by bonding of glycerol, polyamines, and hydroxypropyl‐β‐cyclodextrin for hydrophilic interaction and chiral capillary electrochromatography

机译：羟基甲型前体的后聚合改性。 第三部分。 用环氧官能团激活聚（羟乙基甲基丙烯酸酯 - 共戊丙酮三丙烯酸酯）单片，然后键合甘油，多胺和羟丙基-β-环糊精进行亲水性相互作用和手性毛细管电粒子

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摘要

In this last part of the series of investigations involving the postpolymerization modification of a hydroxy monolith (OHM) capillary column, the surface hydroxyl groups were first reacted with glycerol diglycidyl ether in the presence of boron trifluoride (BF 3 ) to convert the surface into epoxy activated OHM. The column thus activated with epoxy functions was further functionalized with polar compounds such as glycerol and polyamines to yield polyol OHM and polyamine OHM columns, respectively, for use in hydrophilic interaction electrochromatography. In another postpolymerization functionalization of the epoxy‐activated OHM, hydroxypropyl‐β‐CD (HP‐β‐CD) was grafted onto the epoxy OHM surface to produce HP‐β‐CD OHM for enantioseparation by CEC (chiral CEC). The polyol OHM capillary column and polyamine OHM capillary columns exhibited the typical hydrophilic interactions columns vis‐à‐vis polar solutes such as phenolic compounds and nucleobases. The HP‐β‐CD OHM column was able to resolve some racemic compounds as well as positional isomers. All the columns exhibited good reproducibility from run to run, day to day, and column to column.
机译：在该系列研究的最后一部分涉及羟基甲基石英（欧姆）毛细管柱的后聚合修饰中，在硼三氟化硼（BF 3）存在下，首先将表面羟基与甘油二缩水甘油醚反应，将表面转化为环氧树脂活化欧姆。由此用环氧官能团激活的柱用极性化合物进一步官能化，例如甘油和多胺，分别用于产生多元醇欧姆和多胺欧姆柱，用于亲水相互作用电粒子缩影。在环氧活化欧姆的另一个后聚合官能化中，将羟丙基-β-CD（HP-β-CD）接枝到环氧型欧姆表面上，以产生通过CEC（手性CEC）对映映的HP-β-CD欧姆。多元醇欧姆毛细管柱和多胺欧姆毛细管柱表现出典型的亲水性相互作用塔Vis-in-Vis诸如酚类化合物和核碱基的极性溶质。 HP-β-CD OHM柱能够解析一些外消旋化合物以及位置异构体。所有列从运行，日常和列到列，所有列都表现出良好的再现性。

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