A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: synthesis, crystal structure and DNA-binding properties.

Wu H; Huang X; Yuan J; Kou F; Jia F; Liu B; Wang K

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A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: synthesis, crystal structure and DNA-binding properties.

机译：V形配体2,6-双（2-苯并咪唑基）吡啶及其纤维酸盐Mn（II）复合物：合成，晶体结构和DNA结合性能。

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A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine (bbp) and its picrate Mn(II) complex have been synthesized and characterized by elemental analysis, molecular conductivities, (1)H NMR, IR, UV-vis spectra and X-ray single crystal diffraction. The crystal structure of [Mn(bbp)(2)](pic)(2).2DMF is six-coordinated forming a distorted octahedron. The DNA-binding properties of the two compounds were investigated by electronic absorption spectra, fluorescence spectra and viscosity measurements. The experimental results suggest that the two compounds bind to DNA in an intercalation mode. The main reason of the DNA-binding behaviors may be the large coplanar aromatic rings in the V-shaped ligand. As compared to the DNA-binding affinities of the two compounds, the Mn(II) complex is stronger than bbp. This may be due to the V-shaped angle changed.

机译：已经合成了V形配体2,6-双（2-苯并咪唑基）吡啶（BBP）及其纤维物MN（II）复合物，其特征在于元素分析，分子导体，（1）H NMR，IR，UV-Vis 光谱和X射线单晶衍射。 [Mn（BBP）（2）]（PIC）（2）.2DMF的晶体结构是形成扭曲的八面体的六个协调。通过电子吸收光谱，荧光光谱和粘度测量研究了两种化合物的DNA结合性质。实验结果表明，两种化合物以插层模式结合DNA。 DNA结合行为的主要原因可以是V形配体中的大共面芳环。与两种化合物的DNA结合亲和力相比，Mn（II）复合物比BBP强。这可能是由于V形角度改变。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共7页
作者
Wu H; Huang X; Yuan J; Kou F; Jia F; Liu B; Wang K;
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School of Chemical and Biological Engineering Lanzhou Jiaotong University Anning Xilu 88# Lanzhou 730070 PR China.;

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1. A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: synthesis, crystal structure and DNA-binding properties. [J] . Wu H, Huang X, Yuan J, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：V形配体2,6-双（2-苯并咪唑基）吡啶及其苦味酸Mn（II）配合物：合成，晶体结构和DNA结合特性。
2. A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: synthesis, crystal structure and DNA-binding properties. [J] . Wu H, Huang X, Yuan J, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：V形配体2,6-双（2-苯并咪唑基）吡啶及其纤维酸盐Mn（II）复合物：合成，晶体结构和DNA结合性能。
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A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: synthesis, crystal structure and DNA-binding properties.

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