Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes.

Sathyaraj G; Weyhermuller T; Nair BU

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Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes.

机译：新型钌（II）静脉络合物的合成，表征和DNA结合研究。

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Two new ruthenium(II) complexes, [Ru(itpy)2](PF6)2, 1 and [Ru(bitpy)2](PF6)2 2, were synthesized and characterized by ESI-Mass, UV-Visible, 1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex 1 has been characterized crystallographically. Interaction of these complexes with CT-DNA has been studied using absorption and CD spectra. Absorption spectral titration and CD spectral measurements show that complex 1 binds with DNA through intercalation. Complex 2 on the other hand shows dual mode of binding to DNA, groove binding as well as intercalation. Photo nuclease activity of these complexes has been studied using agarose gel electrophoresis and both the complexes have been shown to exhibit photonuclease activity. However, complex 1 has been found to show higher DNA cleaving efficiency compared to complex 2.

机译：两个新的钌（II）配合物，[Ru（ETPY）2]（PF6）2,1和[Ru（Bitpy）2]（PF6）2 2合成，其特征在于ESI质量，UV可见，1H NMR ，荧光光谱和循环伏安法。复合体1已在晶体上表征。使用吸收和CD光谱研究了这些配合物与CT-DNA的相互作用。吸收光谱滴定和CD光谱测量表明复合物1通过插层与DNA结合。另一方面，复合物2显示与DNA的双模结合，沟槽绑定以及插层。使用琼脂糖凝胶电泳研究了这些复合物的照片核酸酶活性，并且已经显示复合物的粘合剂表现出光子核酸酶活性。然而，与复合物2相比，已发现复合物1显示更高的DNA切割效率。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第1期|共8页
作者
Sathyaraj G; Weyhermuller T; Nair BU;
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Chemical Laboratory Central Leather Research Institute CSIR Adyar Chennai 600020 India.;

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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes. [J] . Sathyaraj G, Weyhermuller T, Nair BU European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第1期

机译：新型钌（II）双吡啶吡啶配合物的合成，表征和DNA结合研究。
2. Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes. [J] . Sathyaraj G, Weyhermuller T, Nair BU European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第1期

机译：新型钌（II）静脉络合物的合成，表征和DNA结合研究。
3. Synthesis, characterization, antioxidant activity, and DNA-binding studies of 1-cyclohexyl-3-tosylurea and its Nd(III), Eu(III) complexes. [J] . Xi PX, Xu ZH, Liu XH, Chemical and Pharmaceutical Bulletin . 2008,第4期

机译：1-环己基-3-甲苯磺酰脲及其Nd（III），Eu（III）配合物的合成，表征，抗氧化活性和DNA结合研究。
4. Synthesis and DNA binding studies of Platinum (II) complexes Based on Cyclodextrin [C] . Siping Tang, Yonglan Feng, Zhifeng Xu International Congress on Advanced Materials . 2014

机译：基于环糊精的铂（II）复合物的合成与DNA结合研究
5. Photochemistry of group 8 metal complexes of type [M(bpy)2 cyanogen] (M = iron, ruthenium). Photosynthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) compounds, or, Photoassisted synthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) complexes. [D] . Turner, David Benjamin. 2009

机译：[M（bpy）2氰基]类型的第8组金属配合物的光化学（M =铁，钌）。杂合铁（II）化合物的光合作用和钌（II）化合物的光电离，或者杂合铁（II）化合物的光辅助合成和钌（II）配合物的光电离。
6. A 22-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis stability and fluorescence properties of ruthenium-DNA complexes. [O] . K Wiederholt, L W McLaughlin 1999

机译：用于掺入寡脱氧核苷酸的22-联吡啶配体：钌-DNA复合物的合成稳定性和荧光性质。
7. Synthesis, characterization and DNA binding studies of Ruthenium(II)(bpy)2L2+ where L are derivatives of imidazo4,5-f-1,10-phenanthrolines [O] . Ting T.T.C., Crouse K.A., Ahmad H. 2015

机译：钌（II）（bpy）2L 2+的合成，表征和DNA结合研究，其中L是咪唑并4,5-f -1,10-菲咯啉的衍生物

Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes.

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