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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-(Pd(N3)2(isn)(2)).
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Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-(Pd(N3)2(isn)(2)).

机译：钯（II）含有异种氨基酰胺（ISN）的抗微生物和抗肿瘤活性（ISN）：反式（Pd（N 3）2（ISN）（2））的X射线结构。

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摘要

Complexes of the type trans-[PdX(2)(isn)(2)] {X = Cl (1), N(3) (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was inferred by IR spectroscopy. Single crystal X-ray diffraction determination on 2 showed that coordination geometry around Pd(II) is nearly square planar, with the ligands in a trans configuration. All the compounds demonstrated better in vitro activity against Mycobacterium tuberculosis than isonicotinamide and pyrazinamide. Among the complexes, compound 2 was found to be the most active with MIC of 35.89 muM. Complexes 1-4 were also screened for their in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines.
机译：型转基因的复合物[PDX（2）（ISN）（2）] {X = Cl（1），N（3）（2），SCN（3），NCO（4）; ISN = IsonicotInamide}被合成并评估体外抗微生物和抗肿瘤活性。 IR光谱推断出Isonicotinamide和伪卤化物配体的配位模式。 图2的单晶X射线衍射测定判定显示Pd（II）周围的配位几何形状是几乎是方形平面，在反式构型中具有配体。 所有化合物都表现出比异洛酰胺和吡嗪酰胺的结核分枝杆菌的体外活性更好。 在复合物中，发现化合物2是35.89妈妈的MIC中最活跃的。 还筛选络合物1-4，用于对LM3和LP07鼠细胞系的体外抗肿瘤活性。

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