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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease
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Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease

机译：大麻（CBD）及其类似物概述：癫痫和阿尔茨海默病中的结构，生物活性和神经保护机制

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Herein, 11 general types of natural cannabinoids from Cannabis sativa as well as 50 (-)-CBD analogues with therapeutic potential were described. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy and neurodegenerative diseases were comprehensively clarified. CBD indirectly acts as an endogenous cannabinoid receptor agonist to exert its neuroprotective effects. CBD also promotes neuroprotection through different signal transduction pathways mediated indirectly by cannabinoid receptors. Furthermore, CBD prevents the glycogen synthase kinase 3 beta (GSK-3 beta) hyperphosphorylation caused by A beta and may be developed as a new therapeutic candidate for Alzheimer's disease. (c) 2020 Elsevier Masson SAS. All rights reserved.
机译：这里，描述了来自大麻苜蓿的11种一般类型的天然大麻素以及具有治疗潜力的50（ - ）CBD类似物。 全面澄清了CBD作为癫痫和神经变性疾病治疗候选者的潜在分子机制。 CBD间接充当内源性大麻素受体激动剂，以发挥其神经保护作用。 CBD还通过Cannabinoid受体间接介导的不同信号转导途径促进神经保护途径。 此外，CBD可防止由β引起的糖原合酶激酶3β（GSK-3β）高磷酸化，并且可以作为阿尔茨海默病的新治疗候选者开发。 （c）2020 Elsevier Masson SAS。 版权所有。

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