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首页> 外文期刊>Molecular medicine reports >Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes
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Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes

机译：患有柿子叶片中糖尿肽模型的低血糖作用

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Previously, powdered persimmon leaves have been reported to have glucose- and lipid-lowering effects in diabetic (db/db) mice. As persimmon leaf is commonly consumed as tea, an aqueous extract of persimmon leaves (PLE) was prepared and its anti-diabetic efficacy was investigated. In the present study, PLE was tested for its inhibitory activity on alpha-glucosidase in vitro. An oral maltose tolerance test was performed in diabetic mice. Next, the acute effect of PLE was examined in streptozotocin-induced diabetic mice. Last, the long-term effect of PLE supplementation was assessed in db/db after eight weeks. An oral glucose tolerance test, biochemical parameters, as well as histological analyses of liver and pancreas were evaluated at the end of the study. PLE inhibited alpha-glucosidase activity and increased antioxidant capacity. Streptozotocin-induced diabetic mice pre-treated with PLE displayed hypoglycemic activity. Daily oral supplementation with PLE for eight weeks reduced body weight gain without affecting food intake, enhanced the glucose tolerance during the oral glucose tolerance test (OGTT), improved blood lipid parameters, suppressed fat accumulation in the liver and maintained islet structure in db/db mice. Further mechanistic study showed that PLE protected pancreatic islets from glucotoxicity. In conclusion, the results of the present study indicated that PLE exhibits considerable anti-diabetic effects through alpha-glucosidase inhibition and through the maintenance of functional beta-cells. These results provided a rationale for the use of persimmon leaf tea for the maintenance of normal blood glucose levels in diabetic patients.
机译：以前，据报道，粉末状柿叶在糖尿病（DB / DB）小鼠中具有葡萄糖和降脂效果。作为柿子叶通常被茶作为茶，制备了柿子叶（PLE）的水质提取物，并研究了其抗糖尿病效果。在本研究中，在体外测试α-葡糖苷酶的抑制活性。在糖尿病小鼠中进行口腔畸形耐受试验。接下来，在链脲佐菌素诱导的糖尿病小鼠中检查PLE的急性效果。最后，在八周后，在DB / DB中评估了PLE补充的长期效果。在研究结束时评估了口服葡萄糖耐量试验，生化参数以及肝癌的组织学分析。 PLE抑制α-葡糖苷酶活性和增加的抗氧化能力。用PLE显示出低血糖活性预处理的链脲佐菌素诱导的糖尿病小鼠。每日口服补充八周的八周减少体重增加而不影响食物摄入量，增强了口服葡萄糖耐量试验（OGTT）的葡萄糖耐量，改善了血脂参数，抑制肝脏的脂肪积累并保持在DB / DB中的胰岛结构。老鼠。进一步的机械研究表明，PLE受到葡萄酸毒性的保护胰岛。总之，本研究结果表明，PLE通过α-葡糖苷酶抑制和通过维持功能性β细胞表现出相当大的抗糖尿病作用。这些结果提供了使用柿子叶茶以维持糖尿病患者正常血糖水平的理由。

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