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首页> 外文期刊>Nanotechnology >Physiochemical properties and paclitaxel release behaviors of dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites
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Physiochemical properties and paclitaxel release behaviors of dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites

机译：双刺激响应共聚物 - 磁铁矿超顺磁性纳米复合材料的生理化学性质和紫杉醇释放行为

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摘要

Magnetically driven drug delivery systems of superparamagnetic iron oxide nanoparticles have a considerable potential as candidates to overcome the present obstacles of drug delivery in anti-tumor therapy owing to its remote controllability by external magnetic fields and other unique properties. In this work, a biodegradable anionic copolymer with side carboxylic groups named methoxy-poly (ethylene glycol)-block-poly(alpha-carboxyl-epsilon-caprolactone) was synthesized to complex iron oxide magnetic nanoparticles and load paclitaxel (PTX) to form dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites with an elastic core and carboxylic groups on the surface in a very easy way. The physiochemical properties of these nanocomposites were measured. High PTX loading content and high saturation magnetization were obtained. Being proved to be stable at a wide pH range and low cytotoxic in vitro, these nanocomposites presented faster PTX release in vitro at pH 6.5 than at pH 7.4 and obviously reduced burst release.
机译：磁力驱动的超顺磁性氧化铁纳米粒子的药物输送系统具有相当大的潜力作为候选者，以克服抗肿瘤治疗中药物递送的障碍，由于外部磁场和其他独特性质的远程可控性。在这项工作中，合成了具有甲氧基 - 聚（乙二醇） - 甲基聚（α-羧基 - ε-己内酯）的侧羧基的可生物降解的阴离子共聚物被合成给复合的氧化铁磁性纳米粒子和载荷紫杉醇（PTX）形成双重-Stimuli响应共聚物 - 磁铁矿超顺磁性纳米复合材料以非常简单的方式在表面上具有弹性芯和羧基。测量这些纳米复合材料的物理化学性质。获得高PTX负载含量和高饱和磁化。被证明在体外宽的pH范围和低细胞毒性稳定，这些纳米复合材料在pH6.5的体外呈现出更快的PTX释放，而不是在pH 7.4时，明显降低爆发释放。

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  • 来源
    《Nanotechnology》 |2019年第10期|共14页
  • 作者

    Liu Yu; Li Yang; Rao Zikun; Xu Jinshan; Zhao Shichao; Zhao Cong; Zhu Hongyu; Hao Jianyuan; Yang Ting; Yang Yuan;

  • 作者单位

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Sch Mat &

    Energy Chengdu 610054 Sichuan Peoples R China;

    Sichuan Univ West China Sch Preclin &

    Forens Med Dept Microbiol Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ West China Sch Preclin &

    Forens Med Dept Microbiol Chengdu 610041 Sichuan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    magnetic responsiveness; pH-responsive release; nanocomposites;

    机译：磁反应性;pH响应释放;纳米复合材料;

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