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Bimetallic silver platinum nanoparticles with combined osteo-promotive and antimicrobial activity

机译：双金属银铂纳米颗粒，具有促进骨质促进和抗微生物活性

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摘要

Bimetallic alloyed silver-platinum nanoparticles (AgPt NP) with different metal composition from Ag10Pt90 to Ag90Pt10 in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (>= 50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag50Pt50NP.
机译：双金属合金化银 - 铂纳米颗粒（NP AgPt）具有在20摩尔％以下步骤从Ag10Pt90不同的金属组合物Ag90Pt10合成。 AgPt NP，所述的生物效应，包括细胞摄取，细胞生存力，成骨分化和破骨细胞生成以及向金黄色葡萄球菌和大肠杆菌的抗微生物活性相比于纯Ag NP和纯铂NP进行了分析。 NP的摄取人间充质干细胞是通过在用能量色散X射线分析的组合的横截面聚焦离子束制备和观察通过扫描和透射电子显微镜确认。观察到较低的细胞毒性和抗菌活性AgPt NP相比纯Ag NP。因此，增强的银离子释放由于可能的牺牲阳极作用没有实现。然而，至少50摩尔％Ag含量足以诱导对两种金黄色葡萄球菌和大肠杆菌的杀菌效果。此外，在Pt相关（> = 50摩尔％的Pt）通过增强的细胞钙化和碱性磷酸酶活性观察到对人间充质干细胞骨的促进活性。相反，大鼠原代前体破骨细胞的破骨细胞形成抑制作用。总之，这些结果表明，一个组合子骨的促进和双金属Ag50Pt50NP的抗菌活性。

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  • 来源
    《Nanotechnology》 |2019年第30期|共10页
  • 作者

    Breisch Marina; Grasmik Viktoria; Loza Kateryna; Pappert Kevin; Rostek Alexander; Ziegler Nadine; Ludwig Alfred; Heggen Marc; Epple Matthias; Tiller Joerg C.; Schildhauer Thomas A.; Koeller Manfred; Sengstock Christina;

  • 作者单位

    Ruhr Univ Bochum BG Univ Hosp Bergmannsheil Bochum Surg Res Buerkle de la Camp Pl 1 D-44789 Bochum Germany;

    Univ Duisburg Essen Inorgan Chem &

    Ctr Nanointegrat Duisburg Essen Ce Univ Str 5-7 D-45117 Essen Germany;

    Univ Duisburg Essen Inorgan Chem &

    Ctr Nanointegrat Duisburg Essen Ce Univ Str 5-7 D-45117 Essen Germany;

    Univ Duisburg Essen Inorgan Chem &

    Ctr Nanointegrat Duisburg Essen Ce Univ Str 5-7 D-45117 Essen Germany;

    Univ Duisburg Essen Inorgan Chem &

    Ctr Nanointegrat Duisburg Essen Ce Univ Str 5-7 D-45117 Essen Germany;

    Ruhr Univ Bochum Fac Mech Engn Inst Mat Univ Str 150 D-44780 Bochum Germany;

    Ruhr Univ Bochum Fac Mech Engn Inst Mat Univ Str 150 D-44780 Bochum Germany;

    Res Ctr Julich GmbH Ernst Ruska Ctr ER C Microscopy &

    Spect Electrons D-52425 Julich Germany;

    Univ Duisburg Essen Inorgan Chem &

    Ctr Nanointegrat Duisburg Essen Ce Univ Str 5-7 D-45117 Essen Germany;

    TU Dortmund Univ Inst Biomat &

    Polymer Sci Fac Biochem &

    Chem Engn Emil Figge Str 50 D-44227 Dortmund Germany;

    Ruhr Univ Bochum BG Univ Hosp Bergmannsheil Bochum Surg Res Buerkle de la Camp Pl 1 D-44789 Bochum Germany;

    Ruhr Univ Bochum BG Univ Hosp Bergmannsheil Bochum Surg Res Buerkle de la Camp Pl 1 D-44789 Bochum Germany;

    Ruhr Univ Bochum BG Univ Hosp Bergmannsheil Bochum Surg Res Buerkle de la Camp Pl 1 D-44789 Bochum Germany;

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  • 正文语种 eng
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  • 关键词

    bimetallic nanoparticles; platinum; silver; osteogenic differentiation; antimicrobial activity; osteoclastogenesis;

    机译：双金属纳米粒子;铂;银;骨质发生分化;抗菌活性;骨酸骨质发生;

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