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Facile synthesis of cerium-doped carbon quantum dots as a highly efficient antioxidant for free radical scavenging

机译：铈掺杂碳量子点的容易合成作为自由基清除的高效抗氧化剂

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摘要

Excessive reactive oxygen species (ROS) can lead to irreversible damage to the human body in vivo, therefore it is highly desirable to exploit an efficient antioxidant. Recently, cerium oxide nanoparticles have attracted extensive attention in the field of biomedicine due to their excellent antioxidant properties. In this study, cerium-doped carbon quantum dots (Ce-doped CQDs) with hydroxyl radical scavenging capacity were synthesized for first time by one-step hydrothermal carbonization method. The resultant Ce-doped CQDs with the average particle size of 2.5 nm possessed the properties of good water solubility, colloid stability, and strong fluorescence, which are similar to traditional CQDs. Meanwhile, the Ce-doped CQDs had good biocompatibility and negligible cytotoxicity. Taking advantage of inherent ultra-small size, the Ce-doped CQDs exhibited a high Ce3+/Ce4+ ratio at the surface of particles. The radical scavenging capability of the Ce-doped CQDs was proved by a simple photometric system in vitro, which provided direct evidence for its antioxidant potency. Furthermore, the Ce-doped CQDs had a high ability to protect cells from hydrogen peroxide-induced damage by scavenging hydroxyl radicals. These results suggest that Ce-doped CQDs as a new ROS scavenger may provide potential prospects for the treatment of oxidative stress-related diseases.
机译：过量的活性氧（ROS）可以导致体内对人体的不可逆损伤，因此非常希望利用有效的抗氧化剂。最近，由于其优异的抗氧化性能，氧化铈纳米颗粒在生物医学领域引起了广泛的关注。在本研究中，通过一步水热碳化法首次合成具有羟基自由基清除能力的铈掺杂的碳量子点（CE掺杂的CQDS）。所得Ce掺杂的CQD具有2.5nm的平均粒度的CQD，具有良好的水溶性，胶体稳定性和强荧光的性质，其类似于传统的CQD。同时，CE掺杂的CQD具有良好的生物相容性和可忽略的细胞毒性。利用固有的超小尺寸，CE掺杂的CQD在颗粒表面上表现出高CE3 + / CE4 +比率。通过体外简单的光度系统证明了CE掺杂CQDS的自由基清除能力，为其抗氧化效力提供了直接证据。此外，CE掺杂的CQD具有高能力，通过清除羟基自由基来保护来自过氧化氢损伤的细胞。这些结果表明，CE掺杂的CQD作为新的ROS清除剂可以提供治疗氧化应激相关疾病的潜在前景。

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  • 来源
    《Nanotechnology》 |2019年第32期|共11页
  • 作者

    Zhang Miaomiao; Zhao Lulu; Du Fengting; Wu Yunchao; Cai Rong; Xu Lixia; Jin Hongrui; Zole Shengqiang; Gong Aihua; Du Fengyi;

  • 作者单位

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

    Huangnihe Town Hosp Dept Physiotherapy Dunhua 133705 Peoples R China;

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

    Zhengzhou Univ Dept Magnet Resonance Imaging Affiliated Hosp 1 Zhengzhou 450052 Henan Peoples R China;

    Huangnihe Town Hosp Dept Physiotherapy Dunhua 133705 Peoples R China;

    Jiangsu Univ Affiliated Hosp Zhenjiang 3 Dept Hepatosis Zhenjiang 212013 Jiangsu Peoples R China;

    Jiangsu Univ Sch Med Zhenjiang 212013 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    cerium; antioxidant; carbon quantum dots; radical scavenging;

    机译：铈;抗氧化剂;碳量子点;激进清除;

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