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首页> 外文期刊>Nanotechnology >Synthesis of porphyrin-conjugated silica-coated Au nanorods for synergistic photothermal therapy and photodynamic therapy of tumor
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Synthesis of porphyrin-conjugated silica-coated Au nanorods for synergistic photothermal therapy and photodynamic therapy of tumor

机译：卟啉缀合的二氧化硅涂覆Au纳米型合成协同光热疗法和肿瘤光动力治疗的合成

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Synergistic therapy of tumor has attracted the attention of an increasing number of researchers because of its higher efficiency compared to single therapy. Herein, 4-carboxyphenyl porphyrin-conjugated silica-coated gold nanorods (AuNR@SiO2-TCPP) were synthesized. The synergistic treatment of photothermal therapy and photodynamic therapy on A549 cancer was researched in vivo and in vitro. In the AuNR@SiO2-TCPP, Au NRs and TCPP act as photothermal agent and photosensitizer, respectively. The temperature of the AuNR@SiO2-TCPP (0.11 nmol L-1) rises to 56.8 degrees C for 10 min under the illumination of 808 nm laser (2 Wcm(2)). In MTT assays, the viability of A549 cancer cell treated with AuNR@SiO2-TCPP (100 mu g ml(-1)) is only 21%. In animal experiments, the relative tumor volumes in mice receiving AuNR@SiO2-TCPP (5 mg kg(-1)) with 660 and 808 nm irradiations were significantly inhibited and the average value is decreased to 0.78 while the average value of the control group is increased to 7.2. These results demonstrate that the AuNR@SiO2-TCPP is a potential nanomedicine against tumor for clinical application in the near future.
机译：由于其与单一治疗相比，肿瘤的协同疗法引起了越来越多的研究人员的注意力。本文中，合成了4-羧基苯基卟啉 - 缀合的二氧化硅涂覆的金纳米棒（AUNR @ SiO2-TCPP）。体内和体外研究了A549癌症光热疗和光动力治疗的协同处理。在AUNR @ SIO2-TCPP中，AU NRS和TCPP分别充当光热代理剂和光敏剂。在808nm激光的照明下，AUNR @ SiO2-TCPP（0.11nmol L-1）的温度在808nm激光照射下（2 Wcm（2））的照明上升到56.8℃。在MTT测定中，用AUNR @ SiO2-TCPP处理的A549癌细胞的可行性（100μgml（-1））仅为21％。在动物实验中，接受AUNR @ SiO2-TCPP（5mg kg（-1））的小鼠中的相对肿瘤体积显着抑制，平均值降至0.78，而对照组的平均值增加到7.2。这些结果表明，AUNR @ SIO2-TCPP是在不久的将来对临床应用的临床应用的潜在纳米医生。

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