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Sulforaphane-conjugated selenium nanoparticles: towards a synergistic anticancer effect

机译：亚氟丙烷缀合的硒纳米粒子：朝向协同抗癌效果

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摘要

Sulforaphane-modified selenium nanoparticles can be prepared in a simple aqueous-phase redox reaction through reduction of selenite with ascorbic acid. The sulforaphane molecules present in the reaction mixture adsorb on the nanoparticle surface, forming an adlayer. The resulting conjugate was examined with several physicochemical techniques, including microscopy, spectroscopy, x-ray diffraction, dynamic light scattering and zeta potential measurements. As shown in in vivo investigations on rats, the nanomaterial administered intraperitoneally is eliminated mainly in urine (and, to a lesser extent, in feces); however, it is also retained in the body. The modified nanoparticles mainly accumulate in the liver, but the basic parameters of blood and urine remain within normal limits. The sulforaphane-conjugated nanoparticles reveal considerable anticancer action, as demonstrated on several cancer cell cultures in vitro. This finding is due to the synergistic effect of elemental selenium and sulforaphane molecules assembled in one nanostructure (conjugate). On the other hand, the cytotoxic action on normal cells is relatively low. The high antitumor activity and selectivity of the conjugate with respect to diseased and healthy cells is extremely promising from the point of view of cancer treatment.
机译：通过用抗坏血酸还原，可以通过减少亚硒酸盐在简单的水相氧化还原反应中制备亚磺炔丙烷化硒纳米颗粒。存在于反应混合物中的亚磺烷烷分子吸附在纳米颗粒表面上，形成亚丁层。用几种物理化学技术检查所得的缀合物，包括显微镜，光谱，X射线衍射，动态光散射和Zeta电位测量。如对大鼠的体内研究所示，腹膜内施用的纳米材料主要在尿液中（以及较小程度，粪便）消除;但是，它也保留在体内。改性纳米颗粒主要积聚在肝脏中，但血液和尿液的基本参数仍然在正常限制范围内。如在体外的几种癌细胞培养上所证明的那样，亚磺素缀合的纳米颗粒揭示了相当大的抗癌动作。该发现是由于元素硒和亚磺酸盐分子在一个纳米结构（缀合物）中的协同作用。另一方面，正常细胞上的细胞毒性作用相对较低。患有患病和健康细胞的高抗肿瘤活性和缀合物的选择性来自癌症治疗的观点非常有前景。

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