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Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides

机译:非晶金属硼化物作为乙酰胆碱酯酶生物传感器的开发和有机磷农药的新颖平台

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摘要

The exploration of new materials for modifying electrodes is important to advance electrochemical biosensors. Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. The effects of different composition and crystallinity on its electrochemical performance are investigated, and the optimization studies of the biological transducer were also discussed. Under optimal conditions, the fabricated sensor showed good analytical performance for the determination of chlorpyrifos with a low limit of detection (2.83 pM) and a wide linear range (3 pM-300 nM). The proposed biosensor also demonstrated high reproducibility, stability and accuracy. The impressive performance was due to the excellent conductivity and the unique amorphous bimetal-metalloid complex nanostructure. These results introduce a new class of promising materials as a robust platform for biosensor applications.
机译:改变电极新材料的探索对于推进电化学生物传感器是重要的。在此,我们证明了通过简单和容易水性反应制备的非晶双金属硼化物材料(CO-2NI-B)是一种有效的基质,以固定乙酰胆碱酯酶(ACHE)以构建用于测定有机磷农药的生物传感器。研究了不同组成和结晶度对其电化学性能的影响,还讨论了生物传感器的优化研究。在最佳条件下,制造的传感器显示出良好的分析性能,用于测定具有低限制(2.83μm)和宽线性范围(3 PM-300nm)的紫外线的含氯吡啶酚。所提出的生物传感器还表现出高再现性,稳定性和准确性。令人印象深刻的性能是由于优异的导电性和独特的无定形双金属 - 金属络合物纳米结构。这些结果将一类新的有希望的材料作为生物传感器应用的强大平台。

著录项

  • 来源
    《Nanotechnology》 |2019年第5期|共7页
  • 作者单位

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

    Yanshan Univ Dept Appl Chem Key Lab Appl Chem Qinhuangdao 066004 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    sensor; boride; pesticides;

    机译:传感器;硼化物;杀虫剂;

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