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首页> 外文期刊>Nanotechnology >Simple and cleaner system of silver nanoparticle synthesis using kenaf seed and revealing its anticancer and antimicrobial potential
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Simple and cleaner system of silver nanoparticle synthesis using kenaf seed and revealing its anticancer and antimicrobial potential

机译：使用Kenaf Seed和揭示其抗癌和抗微生物潜力的简单和更清洁的银纳米粒子合成系统

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The clean and eco-friendly synthesis of silver nanoparticles (AgNPs) has provided promising characteristics with impressive biomedical related potential. Here, we have employed a green process for the synthesis of AgNPs using kenaf seed (KS) extract as a bilateral mediator for reducing and capping of Ag+ ions under hydrothermal condition. The synthesis pathways, such as varying amounts of KS, Ag ion concentration and autoclaving time were optimized. The manifestation of a strong absorption peak from 420-430 nm in UV-vis spectroscopy indicated the successful synthesis of KS@AgNPs. Fourier transform infrared spectroscopy confirmed the presence of hydroxyl and carbonyl functionalities involved in the reduction and stabilization of Ag+ ions. Furthermore, transmission electron microscopy revealed that the KS@AgNPs are spherical in shape having a size around 7-11 nm, whereas high-quality crystals were evidenced by x-ray diffraction analysis. Moreover, inductively coupled plasma-optical emission spectrometry revealed that 19.6 mu g l(-1) of Ag+ ions were released from the KS@AgNPs. In cell line studies, KS@AgNPs at a higher dose were shown to be non-toxic to the healthy (NIH3T3) cells, while strong anti-proliferative response was found in the case of lung cancer (A549) cells. Furthermore, a significant zone of inhibition was observed for both Gram-positive and Gram-negative microorganisms, and a combination of KS@AgNPs with ampicillin revealed a notable synergistic anti-pathogenic effect. Overall, our study proved the potentiality of KS as an efficient bio-resource for the synthesis of AgNPs and also its original feature as an anti-cancer and antimicrobial agent.
机译：银纳米粒子（AGNPS）的清洁和环保合成提供了具有令人印象深刻的生物医学相关潜力的有希望的特征。在这里，我们使用了使用Kenaf Seew（Ks）提取物作为双侧介体来合成AgNP的绿色方法，用于在水热条件下降低和封顶Ag +离子。优化了合成途径，例如不同量的Ks，Ag离子浓度和高压灭菌时间。在UV-VIS光谱中420-430nm的强吸收峰的表现表明KS @ AgNP的成功合成。傅里叶变换红外光谱证实了参与Ag +离子的减少和稳定化的羟基和羰基官能团的存在。此外，透射电子显微镜表明，KS @ agnps是尺寸为约7-11nm的形状的球形，而通过X射线衍射分析证明了高质量的晶体。此外，电感耦合等离子体光学发射光谱法显示从KS-agnps释放19.6μg1（-1）的Ag +离子。在细胞系研究中，显示较高剂量的KS @ AgNP对健康（NIH3T3）细胞无毒，而在肺癌（A549）细胞的情况下发现了强的抗增殖反应。此外，针对革兰氏阳性和革兰氏阴性微生物观察到显着的抑制区，并且具有氨苄青霉素的KS-agnps的组合显示出显着的协同抗病效果。总体而言，我们的研究证明了KS作为合成AgNP的有效生物资源的潜力以及其原始特征作为抗癌和抗微生物剂。

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