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Facile synthesis of rGO-MoS2-Ag nanocomposites with long-term antimicrobial activities

机译：具有长期抗微生物活性的RGO-MOS2-AG纳米复合材料的容易合成

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The abuse of antibiotics has led to the emergence of numerous super resistant bacteria, which pose a serious threat to public health. Developing nanomaterials with novel modes of bactericidal activity offers the promise of fighting pathogens without the risk of causing drug resistances. Here, we used reduced graphene oxide (rGO), bulk molybdenum disulfide (MoS2) and silver nitrate (AgNO3) to synthesize a ternary nanocomposite, rGO-MoS2-Ag, via a simple one-pot method. The resulting rGO-MoS2-Ag presented as crumpled and sheet-like structures decorated with Ag nanoparticles. The minimum inhibitory concentration and minimum bactericidal concentration of rGO-MoS2-Ag against Escherichia coli were 50 and 100 mu gml(-1), while Staphylococcus aureus reacted only to twice higher concentrations of 100 and 200 mu gml(-1), respectively. Notably, rGO-MoS2-Ag exhibited better antibacterial activity towards E. coli and S. aureus than rGO, MoS2, or rGO-MoS2. This result can be attributed to the excellent performance of rGO-MoS2-Ag in destroying the bacterial cell membrane and inducing the generation of reactive oxygen species. The Ag+ ion release of rGO-MoS2-Ag was delayed, endowing the nanocomposite with long-term antibacterial capabilities and better biosafety. Our results indicate that the as-prepared rGO-MoS2-Ag has promising potential for application in biomedicine and public health.
机译：滥用抗生素导致了许多超级抗性细菌的出现，这对公共卫生构成了严重的威胁。具有新型杀菌活动模式的开发纳米材料提供了在没有引起耐药性的情况下进行抗击病原体的承诺。在此，我们使用了石墨烯氧化物（RGO），本体钼二硫化物（MOS2）和硝酸银（AgNO3），通过简单的单罐方法合成三元纳米复合材料Rgo-MOS2-AG。由此产生的RGO-MOS2-AG表示为用Ag纳米颗粒装饰的皱折和片状结构。 RGO-MOS2-AG对大肠杆菌的最小抑制浓度和最小杀菌浓度为50-100μgmm（-1），而金黄色葡萄球菌的含量仅为100和200μg（-1）的两倍。值得注意的是，Rgo-MOS2-AG比RGO，MOS2或RGO-MOS2朝向大肠杆菌和S.UUREUS的抗菌活性表现出更好的抗菌活性。该结果可归因于RGO-MOS2-AG在破坏细菌细胞膜并诱导反应性氧物种的产生的优异性能。 rgo-mos2-Ag的Ag +离子释放延迟，赋予纳米复合材料，具有长期抗菌能力和更好的生物安全性。我们的结果表明，AS准备的RGO-MOS2-AG具有有希望在生物医学和公共卫生方面的应用潜力。

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