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首页> 外文期刊>Nanotechnology >Persistent prolate polymersomes for enhanced co-delivery of hydrophilic and hydrophobic drugs
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Persistent prolate polymersomes for enhanced co-delivery of hydrophilic and hydrophobic drugs

机译：持续的聚合物聚合物，用于增强亲水和疏水药物的共同递送

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Self-assembled polymersomes encapsulate, protect, and deliver hydrophobic and hydrophilic drugs. Though spherical polymersomes are effective, early studies suggest that non-spherical structures may enhance specificity of delivery and uptake due to similarity to endogenous uptake targets. Here we describe a method to obtain persistent non-spherical shapes, prolates, via osmotic pressure and the effect of prolates on uptake behavior. Polyethylene glycol-b-poly(lactic acid) polymersomes change in diameter from 145 +/- 6 nm to 191 +/- 1 nm and increase in polydispersity from 0.05 +/- 0.02 to 0.12 +/- 0.01 nm after addition of 50 mM salt. Transmission and scanning electron microscopy confirm changes from spheres to prolates. Prolate-like polymersomes maintain their shape in 50 mM NaCl for seven days. Nile Red and bovine serum albumin-Fluorescein dyes are taken up in greater amounts by SH-SY5Y neural cells when encapsulated in polymersomes. Prolate polymersomes may be taken up more efficiently in neural cells than spherical polymersomes.
机译：自组装聚合物包封，保护和提供疏水性和亲水药物。虽然球形聚合物是有效的，但早期的研究表明，由于与内源摄取靶标相似度，非球形结构可以增强输送和摄取的特异性。在这里，我们描述了一种获得持续的非球形形状的方法，通过渗透压和产物对摄取行为的影响。聚乙二醇-B-聚（乳酸）聚合物的直径从145 +/- 6nm变化到191 +/-1nm，并且在加入50 mm后，从0.05 +/- 0.02至0.12 +/- 0.01nm的多分散性增加盐。传输和扫描电子显微镜确认从球体变化以环节。相似的聚合物在50mM NaCl中保持其形状七天。当在聚合物聚合物中包封时，尼罗红和牛血清白蛋白 - 荧光素染料通过SH-Sy5Y神经细胞占用。可以在神经细胞中比球形聚合物更有效地溶液聚合物聚合物。

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