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首页> 外文期刊>Nanotechnology >A novel cholchicine/gadolinium-loading tubulin self-assembly nanocarrier for MR imaging and chemotherapy of glioma
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A novel cholchicine/gadolinium-loading tubulin self-assembly nanocarrier for MR imaging and chemotherapy of glioma

机译：一种新的Cholclicine / gadolinium-Langumence Disulin自组装纳米骨载体，用于胶质瘤的MR成像和化疗

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摘要

To enhance the therapeutic efficiency and reduce side effects from drug delivery and chemotherapy, image-guided nanoscale systems have attracted tremendous attention in recent decades. In this study, we developed a novel method to fabricate a colchicine/gadolinium-loaded tubulin self-assembly nanocarrier (Col-Gd@Tub NC) for the image-guided chemotherapy of glioma. The Col-Gd@Tub NCs were spontaneously formed via tubulin self-assembly and were subsequently functionalized by colchicine and gadolinium elements. These resultant Col-Gd@Tub NCs with a diameter of 45 nm exhibited uniform particle size distribution and favorable stability without any leakage of gadolinium in water. Meanwhile, the introduction of gadolinium endowed Col-Gd@Tub NCs with high T-1-weighted MRI performance in vitro. After tail vein injection, Col-Gd@Tub NCs exhibited excellent MRI contrast capability and relatively long circulation time (similar to 12 h) and were finally cleared out from the bladder. More significantly, the binding colchicine still exerted an anti-tumor effect after the Col-Gd@Tub NCs were taken up by the tumor cells. These results show that the Col-Gd@Tub NCs may be served as a versatile nanoscale platform for the integration of biomedical imaging probes and therapeutic molecules for tumor therapy.
机译：为了提高药物递送和化疗的治疗效率和减少副作用，近几十年来，图像引导的纳米级系统引起了巨大的关注。在这项研究中，我们开发了一种新的方法，用于制造血清缀/钆的管蛋白自组装纳米载体（COL-GD @桶NC）的胶质瘤的胶质瘤的化学疗法。通过管蛋白自组装自发地形成COL-GD +桶NC，随后通过血氯化汀和钆元素官能化。具有直径为45nm的这些所得Col-Gd桶NC表现出均匀的粒度分布和良好的稳定性，而不会在水中进行任何稀释钆泄漏。同时，在体外引入钆赋予Col-Gd +桶NCS，具有高T-1加权的MRI性能。尾静脉注射后，Col-Gd +桶NCS表现出优异的MRI对比度和相对长的循环时间（类似于12小时），最终从膀胱中清除出来。更重要的是，在肿瘤细胞溶解的Col-Gd @桶NC之后，结合的血基晶仍施加抗肿瘤效果。这些结果表明，COL-GD桶NC可以用作多功能纳米级平台，用于集成生物医学成像探针和治疗分子用于肿瘤治疗。

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