• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Enhanced antibacterial and antiparasitic activity of multifunctional polymeric nanoparticles
【24h】

Enhanced antibacterial and antiparasitic activity of multifunctional polymeric nanoparticles

机译：多官能聚合物纳米粒子的增强抗菌和抗抗原活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Due to the resistance to drugs, studies involving the combination and controlled release of different agents are gradually increasing. In this study, two different active ingredients, known to have antibacterial and antiparasitic activities, were encapsulated into single polymeric nanoparticles. After co-encapsulation their antibacterial and antileishmanial activity was enhanced approximately 5 and 250 times, respectively. Antibacterial and antileishmanial activities of caffeic acid phenethyl ester and juglone loaded, multifunctional nanoformulations (CJ4-CJ6-CJ8) were also evaluated for the first time in the literature comparatively with their combined free formulations. The antibacterial activity of the multifunctional nanoformulation (CJ8) were found to have a much higher activity (MIC values 6.25 and 12.5 mu gml(-1) for S. aureus and E. coli, respectively) than all other formulations. Similar efficacy for CJ8 was obtained in the antiparasitic study against the Leishmania promastigotes and the IC50 was reduced to 0.1263 mu gml(-1). The high activity of multifunctional nanoparticles is not only due to the synergistic effect of the active molecules but also by the encapsulation into polymeric nanoparticles. Therefore, it has been shown in the literature for the first time that the biological activity of molecules whose activity is increased by the synergistic effect can be improved with nanosystems.
机译：由于对药物的抗性，涉及不同剂组合和控释的研究逐渐增加。在该研究中，将两种不同的活性成分，已知具有抗菌和抗寄生虫活性，被包封成单聚合物纳米颗粒。共封装后，它们的抗菌和抗碱性分别增强了约5％和250次。咖啡酸苯乙烷酯和juglone的抗菌和抗菌和抗菌和抗菌癌，也是在文献中首次评估其组合的游离制剂的多官能纳米族种类（CJ4-CJ6-CJ8）。发现多官能纳米造型（CJ8）的抗菌活性分别具有比所有其他配方的含量高得多的活性（MIC值6.25和12.5μgmm（-1））。在针对Leishmania春季的抗披运动会研究中获得CJ8的类似疗效，并且IC50降至0.1263μgmm（-1）。多官能纳米颗粒的高活性不仅是由于活性分子的协同效应，而且是通过将包封剂的协同作用还原成聚合物纳米颗粒。因此，它首次在文献中显示了第一次通过协同效应增加的分子的生物学活性可以用纳米系统改善。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号