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The effect of DNA on the oxidase activity of nanoceria with different morphologies

机译：DNA对不同形态的纳米细胞氧化酶活性的影响

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Many nanomaterials have been reported to have enzyme-like activities and are considered as nanozymes. As a multifunctional nanozyme, nanoceria has received much attention due to the dual oxidation states of Ce3+/Ce4+ which facilitate redox reactions at the particle surface. Despite the advantages of nanozymes, their limited activity and lack of enzyme specificity are still problems to be resolved. DNA is used to modulate the oxidase activity of nanoceria because it has recently become an important molecule in bionanotechnology. However, the current research on the effect of DNA on the oxidase mimetic activity of nanoceria is contradictory. It has been discovered that nanoceria used in recent works are different, including in particle size, doping and concentration, and these differences may affect the interaction between DNA and nanoceria, and then affect the oxidase mimetic activity of nanoceria. Hence, it is important to clarify the factors that affect the interaction between DNA with nanoceria. In this work, the interactions between DNA and nanoceria with three different morphologies (nanoparticles, nanocubes, and nanorods) have been investigated. Experimental results show that DNA has different influences on the oxidase mimetic activity of nanoceria with different morphologies. The oxidase mimetic activity of CeO2 nanoparticles and nanocubes increased, but that of CeO2 nanorods decreased, after DNA modification. The mechanism of these experimental results has been explored, and it has been found that it is the interaction between cerium and the phosphate backbone of DNA that changes with the different morphologies, resulting in the varying effect of DNA on the oxidase mimetic activity of nanoceria. These results may provide a better understanding of the effect of DNA on the oxidase mimetic activity of nanoceria and promote the applications of nanoceria.
机译：据报道许多纳米材料具有类似酶活性的并且被认为是纳米纳豆。作为多官能纳米酶，由于CE3 + / CE4 +的双氧化态，纳米钙受到了很多关注，这促进了颗粒表面的氧化还原反应。尽管纳豆酶的优点，但它们有限的活性和缺乏酶特异性仍然存在解决。 DNA用于调节纳米细胞的氧化酶活性，因为它最近成为Bionanotechnology的重要分子。然而，目前对DNA对纳米氧化酶模拟活性的影响是矛盾的。已经发现，近期作品中使用的纳米细胞是不同的，包括粒度，掺杂和浓度，这些差异可能影响DNA和纳米细胞之间的相互作用，然后影响纳米细胞的氧化酶模拟活性。因此，重要的是要阐明影响DNA与纳米细胞之间相互作用的因素。在这项工作中，已经研究了DNA和纳米细胞的相互作用，具有三种不同的形态（纳米粒子，纳米粒管和纳米棒）。实验结果表明，DNA对具有不同形态的纳米氧化酶模拟活性的影响不同。 CEO2纳米粒子和纳米孔的氧化酶模拟活性增加，但CEO2纳米棒在DNA改性后降低。这些实验结果的机制已探索，并已发现它是铈和DNA的磷酸骨架之间的相互作用，与不同形态的变化，从而导致DNA对纳米氧化铈的氧化酶模拟物活性的变化的效果。这些结果可以更好地理解DNA对纳米钙的氧化酶模拟活性的影响，促进纳米钙的应用。

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