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首页> 外文期刊>Nanotechnology >Ceramic core with polymer corona hybrid nanocarrier for the treatment of osteosarcoma with co-delivery of protein and anti-cancer drug
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Ceramic core with polymer corona hybrid nanocarrier for the treatment of osteosarcoma with co-delivery of protein and anti-cancer drug

机译：陶瓷芯与聚合物电晕杂交纳米载体用于治疗骨肉瘤与蛋白质和抗癌药物的共递送

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For the treatment of metastatic bone cancer, local delivery of therapeutic agents is preferred compared to systemic administration. Delivery of an anti-cancer drug and a protein that helps in bone regeneration simultaneously is a challenging approach. In this study, a nanoparticulate carrier which delivers a protein and an anti-cancer drug is reported. Bovine serum albumin (BSA) as a model protein was loaded into hydroxyapatite (HA) nanoparticles (NPs) and methotrexate (MTX) conjugated to poly(vinyl alcohol) was coated onto BSA-loaded HA NPs. Coating efficiency was in the range of 10-17 wt%. In vitro drug release showed that there was a steady increase in the release of both BSA and MTX with 76% of BSA and 88% of MTX being released in 13 days. Cytotoxicity studies of the NPs performed using human osteosarcoma (OMG-63) cell line showed the NPs were highly biocompatible and exhibited anti-proliferative activity in a concentration-dependent manner.
机译：为了治疗转移性骨癌，与全身给药相比，优选治疗剂的局部递送。 递送抗癌药物和一种有助于骨再生的蛋白质是一种具有挑战性的方法。 在该研究中，报道了一种纳米颗粒载体，其递送蛋白质和抗癌药物。 将牛血清白蛋白（BSA）作为模型蛋白加载到羟基磷灰石（HA）纳米颗粒（NP）中，并将与聚（乙烯醇）缀合的甲氨蝶呤（MTX）涂覆到BSA加载的HA NP上。 涂层效率在10-17wt％的范围内。 体外药物释放表明，BSA和MTX的释放均稳步增加，其中76％的BSA和88％的MTX在13天内被释放。 使用人骨肉瘤（OMG-63）细胞系的NPS的细胞毒性研究表明NPS高度生物相容性，并以浓度依赖性方式表现出抗增殖活性。

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