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Co-delivery of cisplatin and CJM-126 via photothermal conversion nanoparticles for enhanced synergistic antitumor efficacy

机译：通过光热转化纳米颗粒共同递送Cisplatin和CJM-126，用于增强协同抗肿瘤功效

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摘要

Polymeric biomaterials that can be smartly disassembled through the cleavage of the covalent bonds in a controllable way upon an environmental stimulus such as pH change, redox, special enzymes, temperature, or ultrasound, as well as light irradiation, but are otherwise stable under normal physiological conditions have attracted great attention in recent decades. The 2-(4aminophenyl) benzothiazole molecule (CJM-126), as one of the benzothiazole derivatives, has exhibited a synergistic effect with cisplatin (CDDP) and restrains the bioactivities of a series of human breast cancer cell lines. In our study, novel NIR-responsive targeted binary-drug-loaded nanoparticles encapsulating indocyanine green (ICG) dye were prepared as a new co-delivery and combined therapeutic vehicle. The prepared drug-loaded polymeric nanoparticles (TNPs/ CDDP-ICG) are stable under normal physiological conditions, while burst drugs release upon NIR laser irradiation in a mild acidic environment. The results further confirmed that the designed co-delivery platform showed higher cytotoxicity than the single free CDDP due to the synergistic treatment of CJM-126 and CDDP in vitro. Taken together, the work might provide a promising approach for effective site-specific antitumor therapy.
机译：聚合物生物材料可以通过可控方式巧妙地拆卸，以可控的方式在环境刺激，例如pH变化，氧化还原，特殊酶，温度或超声波，以及光照射，但在正常生理下均稳定近几十年来，条件引起了极大的关注。作为苯并噻唑衍生物之一的2-（4氨基苯基）苯并噻唑分子（CJM-126）表现出与顺铂（CDDP）的协同作用，并限制一系列人乳腺癌细胞系的生物活性。在我们的研究中，将包封吲哚菁绿（ICG）染料的新型NIR响应靶向二元药物负载纳米颗粒作为新的共递送和组合治疗载体。制备的药物加载的聚合物纳米颗粒（TNP / CDDP-ICG）在正常生理条件下稳定，而爆破药物在温和酸性环境中的鼻炎激光照射时释放。结果进一步证实，设计的共递送平台由于CJM-126和体外CDDP的协同处理而言，比单一免费的CDDP显示出更高的细胞毒性。在一起，工作可能提供有效的特异性抗肿瘤治疗的有希望的方法。

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