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Magnetite nanoparticle interactions with insulin amyloid fibrils

机译：磁铁矿纳米粒子与胰岛素淀粉样蛋白原纤维相互作用

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Accumulation of amyloid fibrils is one of the likely key factors leading to the development of Alzheimer's disease and other amyloidosis associated diseases. Magnetic nanoparticles (NPs) have been developed as promising medical materials for many medical applications. In this study, we have explored the effects of Fe3O4 NPs on the fibrillogenesis process of insulin fibrils. When Fe3O4 NPs were co-incubated with insulin, Fe3O4 NPs had no effect on the structural transformation into amyloid-like fibrils but had higher affinity toward insulin fibrils. We demonstrated that the zeta potential of insulin fibrils and Fe3O4 NPs were both positive, suggesting the binding forces between Fe3O4 NPs and insulin fibrils were van der Waals forces but not surface charge. Moreover, a different amount of Fe3O4 NPs added had no effect on secondary structural changes of insulin fibrils. These results propose the potential use of Fe3O4 NPs as therapeutic agents against diseases related to protein aggregation or contrast agents for magnetic resonance imaging.
机译：淀粉样蛋白原纤维的积累是导致阿尔茨海默病和其他淀粉样蛋白相关疾病发展的可能关键因素之一。磁性纳米颗粒（NPS）已被开发为许多医疗应用的有前途的医疗材料。在这项研究中，我们探讨了Fe3O4 NP对胰岛素原纤维原纤维生殖过程的影响。当FE3O4 NPS与胰岛素共孵育时，Fe3O4 NPS对淀粉样蛋白样原纤维的结构转化没有影响，但对胰岛素原纤维具有更高的亲和力。我们证明胰岛素原纤维和Fe3O4 NPS的Zeta潜力均为阳性，表明Fe3O4 NPS和胰岛素原纤维之间的结合力是van der WALS力而不是表面电荷。此外，添加了不同量的Fe 3 O 4 NPS对胰岛素原纤维的二次结构变化没有影响。这些结果提出了Fe3O4 NPS作为治疗剂免受与磁共振成像的蛋白质聚集或造影剂相关的疾病的治疗剂。

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