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首页> 外文期刊>Nanotechnology >Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging
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Plasmonic enhancement of cyanine dyes for near-infrared light-triggered photodynamic/photothermal therapy and fluorescent imaging

机译：近红外光触发光动力/光热疗法和荧光成像的青色染料等血浆增强

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摘要

Near-infrared (NIR) triggered cyanine dyes have attracted considerable attention in multimodal tumor theranostics. However, NIR cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacy for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0.4 mu M) based on metal-enhanced fluorescence (MEF) effects. In our design, both the fluorescence intensity and reactive oxygen species of AuNRs@SiO2-IR795 nanocomposites were significantly enhanced up to 51.7 and 6.3 folds compared with free IR795, owing to the localized surface plasmon resonance band of AuNRs overlapping with the absorption or fluorescence emission band of the IR795 dye. Under NIR laser irradiation, the cancer cell inhibition efficiency in vitro with synergetic PDT/PTT was up to 82.3%, compared with 10.3% for free IR795. Moreover, the enhanced fluorescence intensity of our designed nanocomposites was helpful to track their behavior in tumor cells. Therefore, our designed nanoagents highlight the applications of multimodal diagnostics and therapy in tumors based on MEF.
机译：近红外（NIR）触发的青色染料在多峰肿瘤治疗中引起了相当大的关注。然而，肿瘤处理中使用的鼻氰霉素通常患有低荧光强度和弱态氧产生效率，导致肿瘤的诊断和治疗效果不足。改善肿瘤应用中的氰霉病染料的光动力治疗（PDT）和荧光成像（FLI）疗效仍然是一个巨大的挑战。在此，开发了一种新型多功能纳米代理AUNRS @ SiO2-IR795，以实现基于金属增强荧光（MEF）效应的IR795（0.4μm）的非常低剂量的集成光热/光动力治疗（PTT / PDT）和FLI 。在我们的设计中，与自由IR795相比，AUNRS @ SiO2-IR795纳米复合材料的荧光强度和反应性氧气均显着增强至51.7和6.3倍。由于AUNRS与吸收或荧光发射重叠的局部等离子体谐振带IR795染料的带。在NIR激光照射下，具有协同PDT / PTT体外的癌细胞抑制效率高达82.3％，而自由IR795为10.3％。此外，我们所设计的纳米复合材料的增强荧光强度有助于跟踪其在肿瘤细胞中的行为。因此，我们所设计的纳米代理企业突出了基于MEF的多模式诊断和治疗在肿瘤中的应用。

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