Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis

Ye Fang; Li Ningning

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Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis

机译：P15（INK4B）甲基化对骨髓增生综合征患者的作用：系统性荟萃分析

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This meta-analysis was performed to evaluate the role of cyclin-dependent kinase inhibitor 2B (p15(INK4B)) methylation in myelodysplastic syndromes (MDS). p15(INK4B) methylation was significantly higher in MDS than in nontumor controls, higher in advanced MDS than in early MDS, and correlated with worse overall survival. Therefore, p15(INK4B) methylation was associated with MDS development, progression, and prognosis.

机译：进行该荟萃分析以评估细胞周期蛋白依赖性激酶抑制剂2b（p15（墨水4b））甲基化在髓细胞异常综合征（MDS）中的作用。 P15（INK4B）MDS的甲基化显着高于NONTUMOR对照，高于MDS的高级MDS，并且与较差的整体存活率相关。因此，P15（INK4B）甲基化与MDS发育，进展和预后有关。

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《Nature reviews Cancer》 |2019年第6期|共7页
作者
Ye Fang; Li Ningning;
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正文语种 eng
中图分类肿瘤学;
关键词
Development; MDS; Methylation; Prognosis; Progression;

机译：发展;MDS;甲基化;预后;进展;

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1. Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis [J] . Ye Fang, Li Ningning Nature reviews Cancer . 2019,第6期

机译：P15（INK4B）甲基化对骨髓增生综合征患者的作用：系统性荟萃分析
2. Gene silencing of the p15|[sol]|INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes? [J] . M Lübbert Leukemia . 2003,第9期

机译：通过甲基化使p15 | [sol] | INK4B细胞周期抑制剂的基因沉默：骨髓增生异常综合症的早期或后期表观遗传改变？
3. Hypermethylation of the p15~(INK4B) gene in acute leukemia and myelodysplastic syndromes [J] . CHEN Hua, WU Shulan Chinese Medical Journal . 2002,第7期

机译：急性白血病和骨髓增生异常综合症中p15〜（INK4B）基因的高甲基化
4. Ras gene mutation in acute myeloid leukemia and Myelodysplastic syndromes: a meta-analysis of its occurrence and prognostic relevance [C] . Cheng Jingru, Wang Peng, Zhang Tai, International Conference on Advanced Materials and Computer Science . 2016

机译：RAS基因突变在急性髓性白血病和髓细胞增强综合征中：荟萃分析其发生和预后相关性
5. The Efficacy of Extracorporeal Shock Wave Therapy in Comparison to Low-Level Laser Therapy for Decreasing Pain and Symptom Severity and Increasing Functional Status in Adult Patients with Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis [D] . Seely, Andrew. 2021

机译：体外冲击波治疗与低水平激光治疗对脑隧道综合征的成人患者疼痛和症状严重程度及函数状况的疗效：系统评价与荟萃分析
6. P15 gene methylation in hepatocellular carcinomas: a systematic review and meta-analysis [O] . Wei-Hua Ren, Ya-Wei Li, Rui Li, 2015

机译：肝细胞癌中P15基因甲基化的系统评价和荟萃分析
7. Relationship between methylation of the p15 gene in myelodysplastic syndromes (MDS) [O] . H Ohashi, K Tsushita, M Utsumi, 2001

机译：骨髓增生综合征（MDS）中P15基因甲基化的关系

Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis

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