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首页> 外文期刊>Nature reviews Cancer >3,3'-Diindolylmethane mitigates lipopolysaccharide-induced acute kidney injury in mice by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells
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3,3'-Diindolylmethane mitigates lipopolysaccharide-induced acute kidney injury in mice by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells

机译：通过抑制NOx介导的氧化应激和肾小管上皮细胞的凋亡，通过抑制NOx介导的氧化应激和肾小管上皮细胞的凋亡来减轻小学多糖诱导的脂多糖诱导的小鼠急性肾损伤

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摘要

3,3'-Diindolylmethane (DIM) is a naturally derived indole compound found in the Brassica family of vegetables. DIM has several beneficial effects, including anti-cancer, anti-inflammatory and anti-angiogenic functions. However, the effects of DIM on acute kidney injury (AKI) stimulated by lipopolysaccharide (LPS) are poorly studied. In this present study, male BALB/c mouse models of AKI were established using intraperitoneal injections of 10 mg/kg LPS. DIM (40 mg/kg) was administered intraperitoneally 24 and 2 h before LPS exposure. The results indicated that DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine. DIM also suppressed the LPS-induced production of reactive oxygen species and cell apoptosis. Furthermore, DIM treatment significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 in LPS-treated mice. Therefore, DIM may exert its renoprotective actions by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells.
机译：3,3'-二甲基甲烷（DIM）是在甘蓝型蔬菜家族中发现的天然衍生的吲哚化合物。暗淡有几种有益效果，包括抗癌，抗炎和抗血管生成功能。然而，研究脂多糖（LPS）刺激的急性肾脏损伤（AKI）对急性肾脏损伤（LPS）的影响差异。在本研究中，使用10mg / kg LPS的腹膜内注射建立AKI的雄性BALB / C小鼠模型。在LPS暴露之前，腹腔内施用暗淡（40mg / kg）24和2小时。结果表明，暗淡明显减轻肾脏的组织病理学变化，并改善了血尿尿素氮和血清肌酐的水平。 DIM也抑制了LPS诱导的活性氧物质和细胞凋亡的产生。此外，暗淡的处理显着降低了NADPH氧化酶2（NOX2）和NOx4在LPS处理的小鼠中的表达。因此，暗淡可以通过抑制NOx介导的氧化应激和肾小管上皮细胞的凋亡来发挥其逆向防御性作用。

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