Host tissue determinants of tumour immunity

Salmon Helene; Remark Romain; Gnjatic Sacha; Merad Miriam

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Host tissue determinants of tumour immunity

机译：肿瘤免疫宿主组织决定簇

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Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.

机译：虽然常见的进化原理是不管原产地的组织如何促进癌细胞的生长，但肿瘤产生的微环境基本上不同于各种器官位点。最近的研究已经确定，除细胞内在效果外，肿瘤生长调节还取决于由组织环境因素驱动的本地线索。在这篇综述中，我们讨论了组织特异性的决定因素如何影响肿瘤发育，并争辩说解开对肿瘤免疫的组织特异性贡献应该有助于癌症患者的精确免疫治疗策略的发展。

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《Nature reviews Cancer》 |2019年第4期|共13页
作者
Salmon Helene; Remark Romain; Gnjatic Sacha; Merad Miriam;
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Icahn Sch Med Mt Sinai Dept Ontol Sci New York NY 10029 USA;

Innate Pharma Marseille France;

Icahn Sch Med Mt Sinai Dept Ontol Sci New York NY 10029 USA;

Icahn Sch Med Mt Sinai Dept Ontol Sci New York NY 10029 USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Host tissue determinants of tumour immunity [J] . Salmon Helene, Remark Romain, Gnjatic Sacha, Nature reviews Cancer . 2019,第4期

机译：肿瘤免疫宿主组织决定簇
2. Innate Immune Tissue Injury and Murine HGA: Tissue Injury in the Murine Model of Granulocytic Anaplasmosis Relates to Host Innate Immune Response and Not Pathogen Load [J] . DIANA G. SCORPIO, FRIEDERIKE D. VON LOEWENICH, CHRISTIAN BOGDAN, Annals of the New York Academy of Sciences . 2005,第Dec期

机译：先天性免疫组织损伤和小鼠HGA：粒细胞性胞质缺乏症的小鼠模型中的组织损伤与宿主先天性免疫反应有关，而不是病原体负荷
3. Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice [J] . Janet Lau, Jeanne Cheung, Armando Navarro, Nature Communications . 2017,第1期

机译：需要肿瘤和宿主细胞PD-L1来介导小鼠抗肿瘤免疫的抑制
4. Formal Modeling of the Key Determinants of Hepatitis C Virus (HCV) Induced Adaptive Immune Response Network: An Integrative Approach to Map the Cellular and Cytokine-Mediated Host Immune Regulations [C] . Ayesha Obaid, Anam Naz, Shifa Tariq Ashraf, International conference on computational science and its applications . 2018

机译：丙型肝炎病毒（HCV）诱导的适应性免疫反应网络的关键决定因素的形式化建模：映射细胞和细胞因子介导的宿主免疫调节的综合方法
5. Investigation of Intra-tumour Heterogeneity and Host Immune Response in Triple-Negative Breast Cancer [D] . Balde, Zaldy Sirios. 2020

机译：三重阴性乳腺癌中肿瘤内异质性和宿主免疫应答的研究
6. Protein metabolism in the tumour-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumour at different stages in tumour growth. [O] . M N Lopes, P Black, A J Ashford, 1989

机译：荷瘤小鼠中的蛋白质代谢。在肿瘤生长的不同阶段宿主组织和艾氏腹水肿瘤中蛋白质的合成速率。
7. Mathematical modelling of tumour growth and interaction with host tissue and the immune system [O] . Trisilowati 2013

机译：肿瘤生长以及与宿主组织和免疫系统相互作用的数学模型

Host tissue determinants of tumour immunity

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