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首页> 外文期刊>NeuroImage >Monotonic non-linear transformations as a tool to investigate age-related effects on brain white matter integrity: A Box-Cox investigation
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Monotonic non-linear transformations as a tool to investigate age-related effects on brain white matter integrity: A Box-Cox investigation

机译：单调非线性变换作为调查年龄相关效果对脑白质诚信的工具：箱体考核

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摘要

Non-linear effects of age on white matter integrity are ubiquitous in the brain and indicate that these effects are more pronounced in certain brain regions at specific ages. Box-Cox analysis is a technique to increase the loglikelihood of linear relationships between variables by means of monotonic non-linear transformations. Here we employ Box-Cox transformations to flexibly and parsimoniously determine the degree of non-linearity of age-related effects on white matter integrity by means of model comparisons using a voxel-wise approach. Analysis of white matter integrity in a sample of adults between 20 and 89 years of age (n=88) revealed that considerable portions of the white matter in the corpus callosum, cerebellum, pallidum, brainstem, superior occipitofrontal fascicle and optic radiation show non-linear effects of age. Global analyses revealed an increase in the average non-linearity from fractional anisotropy to radial diffusivity, axial diffusivity, and mean diffusivity. These results suggest that Box-Cox transformations are a useful and flexible tool to investigate more complex non-linear effects of age on white matter integrity and extend the functionality of the Box-Cox analysis in neuroimaging. (C) 2015 Elsevier Inc. All rights reserved.
机译：年龄对白质完整性的非线性效应在大脑中普遍存在，表明这些效果在特定年龄的某些脑区中更加明显。 Box-Cox分析是通过单调非线性变换来增加变量与变量之间的线性关系的Logliki的技术。在这里，我们采用Box-Cox转换来灵活地，通过使用Voxel-Wise方法的模型比较来灵活地确定与白质诚信的年龄相关的效果的非线性程度。在20至89岁之间的成人样本中的白质完整性（n = 88）揭示了胼callosum，小脑，苍白，脑干，高级枕形雌刺和视光辐射的相当大量的白质。非年龄的线性效应。全局分析显示，分数各向异性的平均非线性增加到径向扩散，轴向扩散性和平均扩散性。这些结果表明，Box-Cox转化是一种有用且灵活的工具，用于研究年龄对白质完整性的更复杂的非线性效果，并延长神经影像动物盒-Cox分析的功能。 （c）2015 Elsevier Inc.保留所有权利。

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  • 来源
    《NeuroImage》 |2016年第null期|共12页
  • 作者

    Morozova Maria; Koschutnig Karl; Klein Elise; Wood Guilherme;

  • 作者单位

    Karl Franzens Univ Graz Dept Psychol Graz Austria;

    Karl Franzens Univ Graz Dept Psychol Graz Austria;

    Knowledge Media Res Ctr Tuebingen Tubingen Germany;

    Karl Franzens Univ Graz Dept Psychol Graz Austria;

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  • 正文语种 eng
  • 中图分类 诊断学;
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