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首页> 外文期刊>NeuroImage >Suprathreshold fiber cluster statistics: Leveraging white matter geometry to enhance tractography statistical analysis
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Suprathreshold fiber cluster statistics: Leveraging white matter geometry to enhance tractography statistical analysis

机译：Suprathreshold纤维簇统计：利用白质几何来增强牵引统计分析

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摘要

This work presents a suprathreshold fiber cluster (STFC) method that leverages the whole brain fiber geometry to enhance statistical group difference analyses. The proposed method consists of 1) a well-established study-specific data-driven tractography parcellation to obtain white matter tract parcels and 2) a newly proposed nonparametric, permutation-test-based STFC method to identify significant differences between study populations. The basic idea of our method is that a white matter parcel's neighborhood (nearby parcels with similar white matter anatomy) can support the parcel's statistical significance when correcting for multiple comparisons. We propose an adaptive parcel neighborhood strategy to allow suprathreshold fiber cluster formation that is robust to anatomically varying inter-parcel distances. The method is demonstrated by application to a multi-shell diffusion MRI dataset from 59 individuals, including 30 attention deficit hyperactivity disorder patients and 29 healthy controls. Evaluations are conducted using both synthetic and in-vivo data. The results indicate that the STFC method gives greater sensitivity in finding group differences in white matter tract parcels compared to several traditional multiple comparison correction methods.
机译：这项工作提出一个超阈值纤维簇（STFC）方法，它利用全脑纤维几何形状以提高统计组差异分析。所提出的方法包含：1）一个完善的研究特定的数据驱动的束成像到地块划分获得白质道包裹和2）一个新提出的非参数的，基于置换检验STFC方法来确定研究人群之间显著差异。我们的方法的基本思想是，校正多重比较，当白质包裹的附近（附近有类似的白质解剖包裹），可以支持包裹的统计学意义。我们提出了一个自适应包裹邻里策略允许阈上光纤集群的形成是稳健的解剖学变化，地块间的距离。该方法由应用程序来的多壳扩散MRI数据集证实从59名个人，包括30注意缺陷多动障碍的患者和29个健康对照。评价是使用合成的和被检体内的数据进行的。该结果表明，STFC方法给出在寻找相比几个传统的多重比较校正方法在白质束的包裹组的差异更大的灵敏度。

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  • 来源
    《NeuroImage》 |2018年第2018期|共14页
  • 作者

    Zhang Fan; Wu Weining; Ning Lipeng; McAnulty Gloria; Waber Deborah; Gagoski Borjan; Sarill Kiera; Hamoda Hesham M.; Song Yang; Cai Weidong; Rathi Yogesh; ODonnell Lauren J.;

  • 作者单位

    Harvard Med Sch Brigham &

    Womens Hosp Boston MA 02115 USA;

    Harvard Med Sch Brigham &

    Womens Hosp Boston MA 02115 USA;

    Harvard Med Sch Brigham &

    Womens Hosp Boston MA 02115 USA;

    Harvard Med Sch Boston Childrens Hosp Boston MA USA;

    Harvard Med Sch Boston Childrens Hosp Boston MA USA;

    Harvard Med Sch Boston Childrens Hosp Boston MA USA;

    Harvard Med Sch Boston Childrens Hosp Boston MA USA;

    Harvard Med Sch Boston Childrens Hosp Dept Psychiat Boston MA USA;

    Univ Sydney Sch Informat Technol Sydney NSW Australia;

    Univ Sydney Sch Informat Technol Sydney NSW Australia;

    Harvard Med Sch Brigham &

    Womens Hosp Boston MA 02115 USA;

    Harvard Med Sch Brigham &

    Womens Hosp Boston MA 02115 USA;

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  • 正文语种 eng
  • 中图分类 诊断学;
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