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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Transcranial direct current stimulation (tDCS) priming of 1Hz repetitive transcranial magnetic stimulation (rTMS) modulates experimental pain thresholds.
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Transcranial direct current stimulation (tDCS) priming of 1Hz repetitive transcranial magnetic stimulation (rTMS) modulates experimental pain thresholds.

机译：1Hz重复经颅磁刺激（RTMS）的经颅直流刺激（TDCS）灌注调节实验疼痛阈值。

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摘要

Transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) of primary motor cortex (M1) modulate cortical excitability. Both techniques have been demonstrated to modulate chronic pain and experimental pain thresholds, but with inconsistent effects. Preconditioning M1 with weak tDCS (1mA) standardizes the effects of subsequent stimulation via rTMS on levels of cortical excitability. Here we examine whether 1Hz rTMS, primed with tDCS, could effectively standardize the modulation of pain thresholds. Thermal pain thresholds were determined using quantitative sensory testing (QST) of the palmar thenar of both hands in 12 healthy males pre and post tDCS - 1Hz rTMS over the hand area of the left M1. Cathodal tDCS preconditioning of 1Hz rTMS successfully reversed the normal suppressive effect of low frequency rTMS and effectively modulated cold and heat pain thresholds. Conversely, anodal tDCS - 1Hz rTMS led to a decrease in cold pain thresholds. Therefore, this study supports that preconditioning M1 using cathodal tDCS before subsequent stimulation via 1Hz rTMS facilitates the production of analgesia.
机译：经颅直流刺激（TDC）和重复的经颅磁刺激（RTMS）的初级电机皮质（M1）调节皮质兴奋性。两种技术都已证明调节慢性疼痛和实验疼痛阈值，但效果不一致。具有弱TDCS（1MA）的预处理M1（1mA）通过RTMS对皮质兴奋性水平标准化随后刺激的影响。在这里，我们检查1Hz RTM是否与TDC一起灌注，可以有效地标准化疼痛阈值的调制。使用12个健康的男性在左M1的手面积上的12个健康的男性中，在12个健康的男性中，使用Palmar Bealar的定量感官测试（QST）测定热疼痛阈值。阴极TDCS预处理1Hz RTMS成功逆转了低频RTMS的正常抑制效果，有效地调制了冷热疼痛阈值。相反，AnoDal TDCS - 1Hz RTMS导致冷疼痛阈值下降。因此，该研究支持在随后通过1Hz RTMS刺激之前使用阴极TDC的预处理M1促进镇痛的产生。

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