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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease
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Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease

机译：中链甘油三酯基酮晶酮化公式对轻度至中等阿尔茨海默病患者认知功能的影响

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Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain and has neuroprotective effects, but the clinical evidence is still scarce. Here we examined the effect of an MCT-based ketogenic formula on cognitive function in patients with Alzheimer's disease (AD). The subjects were 20 Japanese patients with mild-to-moderate AD (11 males, nine females, mean age 73.4 +/- 6.0 years) who, on separate days, underwent neurocognitive tests 120 min after consuming 50 g of a ketogenic formula (Ketonformula (R)) containing 20 g of MCTs or an isocaloric placebo formula without MCTs. The patients then took 50 g of the ketogenic formula daily for up to 12 weeks, and underwent neurocognitive tests monthly. In the first trial, although the patients' plasma levels of ketone bodies were successfully increased 120 min after the single intake of the ketogenic formula, there was no significant difference in any cognitive test results between the administrations of the ketogenic and placebo formulae. In the subsequent chronic intake trial of the ketogenic formula, 16 of the 20 patients completed the 12-week regimen. At 8 weeks after the trial's start, the patients showed significant improvement in their immediate and delayed logical memory tests compared to their baseline scores, and at 12 weeks they showed significant improvements in the digit-symbol coding test and immediate logical memory test compared to the baseline. The chronic consumption of the ketogenic formula was therefore suggested to have positive effects on verbal memory and processing speed in patients with AD.
机译：临床和动物研究表明，基本链甘油三酯（MCT）基础酮蛋白（MCT）为脑部提供替代能源基质并具有神经保护作用，但临床证据仍然稀缺。在这里，我们研究了基于MCT的酮酮配方对阿尔茨海默病患者（AD）患者认知功能的影响。受试者是20名日本人患有轻度至中度的广告（11名男性，九个女性，平均73.4 +/- 6.0岁），在单独的日子里，在消耗50g酮酮的酮酮（Ketonformula）后，在单独的日子中进行了120分钟的神经认知试验（R））含有20g MCT或不含MCT的异孔安慰剂配方。然后患者每天服用50克酮酮配方，长达12周，并每月进行神经认知测试。在第一次试验中，虽然酮酮体的血浆水平成功增加120分钟后酮酮式的酮类分析，但在酮酮和安慰剂配方的给药之间的任何认知测试结果中没有显着差异。在随后的慢性摄入试验中的酮化配方中，20例患者中的16例完成了12周的方案。在审判开始后的8周，与基线评分相比，患者的直接和延迟逻辑记忆试验表现出显着改善，并且在12周时，它们在数字符号编码测试和立即逻辑记忆测试中显示出显着的改进基线。因此，酮类的慢性消耗表明对广告患者的口头记忆和加工速度具有积极影响。

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