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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >The role of taurine on anxiety-like behaviors in zebrafish: A comparative study using the novel tank and the light-dark tasks
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The role of taurine on anxiety-like behaviors in zebrafish: A comparative study using the novel tank and the light-dark tasks

机译：牛磺酸对斑马鱼的焦虑行为的作用：使用小坦克和浅黑色任务的比较研究

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Taurine (TAU) is an amino sulfonic acid with several functions in central nervous system. Mounting evidence suggests that it acts in osmoregulation, neuromodulation and also as an inhibitory neurotransmitter. However, the effects of TAU on behavioral functions, especially on anxiety-related parameters, are limited. The adult zebrafish is a suitable model organism to examine anxiety-like behaviors since it presents neurotransmitter systems and behavioral functions evolutionary conserved. Anxiety in zebrafish can be measured by different tasks, analyzing the habituation to novelty, as well as the response to brightly lit environments. The aim of this study was to investigate whether acute TAU treatment alters anxiety like behavior in zebrafish using the novel tank and the light-dark tests. Fish were individually treated with TAU (42, 150, and 400 mg/L) for 1 h and the behaviors were further analyzed for 6 min in the novel tank or in the light-dark test. Control fish were handled in a similar manner, but kept only in home tank water. Although TAU did not alter locomotor and vertical activities, all concentrations significantly increased shuttling and time spent in lit compartment. Moreover, TAU 150 group showed a significant decrease in the number of risk assessment episodes. Overall, these data suggest that TAU exerts an anxiolytic-like effect in zebrafish and the comparative analysis of behavior using different tasks is an interesting strategy for neuropsychiatric studies related to anxiety in this species. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：牛磺酸（TAU）是氨基磺酸，在中枢神经系统中的若干功能。越来越多的证据表明，它的作用渗透调节，神经调节，也可以作为一种抑制性神经递质。但是，对行为的功能，特别是在焦虑相关参数TAU的影响，被限制。在成年斑马鱼是一种合适的模式生物研究的焦虑样的行为，因为它提出了神经递质系统和行为功能进化保守。在斑马鱼中的焦虑可以通过不同的任务进行测定，分析该习惯新颖性，以及对通明环境的响应。这项研究的目的是急性治疗TAU变造焦虑像斑马鱼的行为是否使用新型坦克和明暗试验进行调查。鱼分别用TAU（42，150，和400毫克/升）处理1个小时，并进一步分析6分钟在新颖槽或明暗测试行为。控制鱼以类似的方式处理，但只能在家里鱼缸水保持。虽然TAU不改变运动和垂直活动中，所有浓度显著上升穿梭在点燃室中花费的时间。此外，TAU 150组表现出风险评估事件的数量显著下降。总体而言，这些数据表明，TAU的发挥抗焦虑样的斑马鱼，并使用不同的任务行为的对比分析作用是在这一物种有关的焦虑神经精神研究的一个有趣的策略。 （c）2015 Elsevier Ireland Ltd.保留所有权利。

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