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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam
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Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam

机译：由Riluzole和DiazePam证实的肌萎缩外壳病变狼猫小鼠模型的兴奋性抑制性不平衡

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Highlights ? Drugs have distinct effects on the brain of the wobbler mouse model of ALS. ? Riluzole demonstrated more pronounced effects on wobbler mice compared to controls. ? Diazepam displayed reduced effects on wobbler individuals compared to controls. ? Drug effects on paired-pulses and initial facilitation during trains were comparable. Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. So far, no cure exists, prompting studies in disease mechanisms to facilitate development of new treatment strategies. In this study, we employed the wobbler mouse model of ALS focusing on a symptomatic group of animals. We studied the neurophysiological changes conferred by riluzole or diazepam application, two drugs employed in ALS. Riluzole is an antiglutamatergic agent and the only drug to offer some effect on the life expectancy of ALS patients. To target the inhibitory system, we utilized diazepam as a GABAergic modulator. Acute brain slices were prepared from the wobbler mouse model and analyzed using extracellular field recordings in the hippocampus. During Schaffer collateral stimulation, riluzole caused a marked reduction in the paired-pulse ratio (p
机译：强调 ？药物对摇摆鼠标模型的脑袋有明显的影响。还是与对照相比，Riluzole对摇滚小鼠进行了更明显的影响。还是与对照相比，Diazepam对摇摆物的效果减少。还是对火车期间对配对脉冲和初始促进的药物影响是可比的。摘要肌营养的外侧硬化症（ALS）是一种毁灭性的神经退行性疾病。到目前为止，不存在治愈，促使疾病机制的研究促进新治疗策略的发展。在这项研究中，我们雇用了摇摆物的ALS小鼠模型，专注于症状的动物组。我们研究了利脲或Diazepam应用程序赋予的神经生理变化，两种用于ALS的药物。 Riluzole是一种抗脱蛋白剂和唯一对ALS患者预期寿命提供一些影响的药物。为了靶向抑制系统，我们将Diazepam用作加巴泮。从摇摆鼠模型制备急性脑切片，并在海马中使用细胞外场记录分析。在Schaffer抵押品刺激期间，Riluzole导致配对脉冲比的显着降低（P

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