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首页> 外文期刊>New Journal of Chemistry >Multimodal therapies: glucose oxidase-triggered tumor starvation-induced synergism with enhanced chemodynamic therapy and chemotherapy
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Multimodal therapies: glucose oxidase-triggered tumor starvation-induced synergism with enhanced chemodynamic therapy and chemotherapy

机译：多式疗法：葡萄糖氧化酶触发肿瘤饥饿诱导的增强增量增强化学疗法和化疗

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摘要

A tumor microenvironment is distinct from normal tissue cells in characteristic physiochemical conditions, based on which we can design tumor-specific therapy modalities. Herein, we introduce a concept of multimodal therapies, which integrates the characteristics of each therapy modality for efficient tumor therapy: tumor starvation-triggered synergism with enhanced chemodynamic therapy and activated chemotherapy. Fe3O4 nanoparticles (Fenton reaction catalysts) and a hypoxic prodrug tirapazamine (TPZ) were loaded in mesoporous silica nanoparticles (MSN) and GOX was grafted onto its surface, which was designed and fabricated for sequential multimodal therapies. Logically, glucose oxidase (GOX) deprived tumor cells of nutrients (glucose and oxygen) for starvation therapy and tumorous abnormality amplifications (elevated acidity, exacerbated hypoxia, and increased H2O2) were amplified by the GOX-driven oxidation reaction simultaneously. Specifically, elevated acidity could accelerate the release of iron ions and enhanced Fenton reaction efficiency. Associated with increased H2O2, an elevated ROS level was detected, which enhanced the chemodynamic therapy. Exacerbated hypoxia activated the hypoxic prodrug TPZ for tumor-specific chemotherapy programmatically. Particularly, via integrating starvation therapy, enhanced chemodynamic therapy, and activated chemotherapy, the sequential multimodal therapies were specifically designed for the tumor microenvironment and achieved effective abnormality amplifications and high therapeutic efficacy.
机译：肿瘤微环境与特征生理条件下的正常组织细胞不同，基于我们可以设计肿瘤特异性治疗方式。在此，我们介绍了多式化疗法的概念，这与有效肿瘤治疗的每种治疗方式的特征相结合：肿瘤饥饿引发的协同作用，具有增强的化学动力学治疗和活化化疗。将Fe3O4纳米颗粒（Fenton反应催化剂）和缺氧前药Tirapazamine（TPZ）加载到介孔的二氧化硅纳米粒子（MSN）中，将GOX接枝到其表面上，该表面设计和制造用于连续的多式联运疗法。逻辑上，通过GOX驱动的氧化反应同时扩增葡萄糖氧化酶（GOX）剥夺营养（葡萄糖和氧气）的营养（葡萄糖和氧气）的肿瘤细胞（葡萄糖和氧化，并且升高的H2O2）。具体地，升高的酸度可以加速铁离子的释放和增强的芬顿反应效率。与H 2 O 2增加相关，检测到升高的ROS水平，这增强了化学动力学疗法。加剧低氧激活肿瘤特异性化疗缺氧前药TPZ编程。特别是，通过整合饥饿治疗，增强的化学动力学治疗和活化化疗，序列多峰疗法专门为肿瘤微环境设计并实现了有效的异常扩增和高治疗效果。

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  • 来源
    《New Journal of Chemistry》 |2020年第4期|共13页
  • 作者

    Cheng Kaiwu; Ling Chuxuan; Gu Dihai; Gao Zhiguo; Li Yaojia; An Peijing; Zhang Yu; You Chaoqun; Zhang Rui; Sun Baiwang;

  • 作者单位

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

    Nanjing Forestry Univ Coll Chem Engn Nanjing 210037 Peoples R China;

    Southeast Univ Zhongda Hosp Dept Ophthalmol Nanjing 210009 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Nanjing 210089 Peoples R China;

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