...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>New Journal of Chemistry >Exploratory studies of a multidimensionally talented simple Mn-II-based porous network: selective 'turn-on' recognition @ cysteine over homocysteine with an indication of cystinuria and renal dysfunction
【24h】

Exploratory studies of a multidimensionally talented simple Mn-II-based porous network: selective 'turn-on' recognition @ cysteine over homocysteine with an indication of cystinuria and renal dysfunction

机译：探讨了多利率的简单Mn-II多孔网络的探索性研究：在同型半胱氨酸上的选择性“开启”识别@半胱氨酸，指示胱氨酸和肾功能不全

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Selective sensing of biothiols holds immense importance due to the adverse roles of abnormal concentrations of biothiols in several diseases, henceforth demanding widespread research for developing a sensory receptor towards the selective detection of biothiols. Herein the designed synthesis of a simple 3D porous coordination polymer,PCP-1 has been carried out following a conventional solvothermal reaction route that shows selective sensing of biothiols (Cys & Hcy) at the nanomolar level with a very short response time carrying enormous importance for simplistic biological studies. Due to the presence of paramagnetic metal centres, Mn-II-MOF itself remains in a quenched state that shows selective "turn-on" fluorescence response in the presence of electron-rich biothiols which was thoroughly studied by DFT. In continuation, the sensor PCP-1 was equally responsive in different biological matrices such as fresh bovine serum and human urine showing the bio-applicability of the porous network which is of immense importance in analytical domains in the modern era. Thus, the detection of biothiols from human urine would be enormously helpful in preparing a paediatric reference range for clinical use. As a result, the detection of eithercystinuriaorhomocystinuriain patients will be done with ease. Additionally,PCP-1 has selective adsorption capability of CO2 over N-2 at low temperature with the aid of the size-exclusion effect of interstitial channels along with the dipole-induced dipole interaction. The magnetic properties of the framework,PCP-1 indicate weak anti-ferromagnetic coupling between the Mn-II centres of the trinuclear building block. These two hidden potentials may be properly utilised in the domain of GHG mitigating agents and spintronic applications, respectively.
机译：生物离子的选择性感应具有巨大的重要性，因为异常浓度在几种疾病中生物素浓度的不利作用，因此要求对开发感觉受体朝着选择性检测生物噻菌醇的普遍研究苛刻的研究。在此，在常规的溶剂热反应途径之后进行了简单的3D多孔配位聚合物，PCP-1，在纳米摩尔水平的常规溶剂热反应途径之后进行了常规的溶剂热反应途径，其具有非常短的响应时间对纳米摩尔（Cys＆Hcy）进行选择性感测简单的生物学研究。由于存在顺磁金属中心，Mn-II-MOF本身保持在淬火状态，显示在通过DFT彻底研究的电子富含电子的生物噻硫醇的存在下选择性的“开启”荧光反应。在延续中，传感器PCP-1在不同的生物基质中同样响应于新鲜的牛血清和人类尿液，显示多孔网络的生物适用性，这在现代时代的分析域中具有巨大的重要性。因此，从人尿中检测来自人尿的生物醇在制备临床用途的儿科参考范围时非常有助于。结果，将易于轻松地进行ETHERCYSTINURIAORHOMYSTINURIAIN患者的检测。另外，PCP-1借助于间隙通道的尺寸排除效果以及偶极子诱导的偶极相互作用，在低温下具有在低温下的CO 2的选择性吸附能力。框架的磁性特性，PCP-1表示三核构建块的MN-II中心之间的弱抗铁磁耦合。可以分别在温室气体缓解剂和旋转反应应用的结构领域适当地利用这两个隐藏电位。

著录项

  • 来源
    《New Journal of Chemistry》 |2020年第34期|共11页
  • 作者

    Bej Sourav; Hazra Abhijit; Das Riyanka; Saha Sourav Kr; Corbella Montserrat; Banerjee Priyabrata;

  • 作者单位

    CSIR Cent Mech Engn Res Inst Surface Engn &

    Tribol Grp Mahatma Gandhi Ave Durgapur 713209 India;

    CSIR Cent Mech Engn Res Inst Surface Engn &

    Tribol Grp Mahatma Gandhi Ave Durgapur 713209 India;

    CSIR Cent Mech Engn Res Inst Surface Engn &

    Tribol Grp Mahatma Gandhi Ave Durgapur 713209 India;

    CSIR Cent Mech Engn Res Inst Surface Engn &

    Tribol Grp Mahatma Gandhi Ave Durgapur 713209 India;

    Univ Barcelona Dept Inorgan Chem Barcelona Spain;

    CSIR Cent Mech Engn Res Inst Surface Engn &

    Tribol Grp Mahatma Gandhi Ave Durgapur 713209 India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号