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首页> 外文期刊>New Journal of Chemistry >Nano iron-copper alloys for tumor ablation: efficiently amplified oxidative stress through acid response
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Nano iron-copper alloys for tumor ablation: efficiently amplified oxidative stress through acid response

机译：用于肿瘤消融的纳米铁铜合金：通过酸反应有效扩增氧化胁迫

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摘要

Efficiently, enhancing intracellular oxidative stressviaincreasing intracellular hydroxyl radicals (center dot OH), which is based on the Fenton reaction and lowering glutathione (GSH) is a promising approach for cancer treatment. Herein, we synthesized a new alloy nanomaterial, Fe5Cu3O@BSA (FCB) with good dispersity aimed at introducing copper ions to improve the Fenton reaction efficiency and reduce GSH. Under the weak acid microenvironment at the tumor, FCB can release Fe(2+)and Cu(2+)and the released free electrons are expected to combine with oxygen to further generate H2O2, leading to an excessive production of H(2)O(2)in the cells. Meanwhile, the released Fe(2+)and Cu(2+)can not only perform a higher reaction efficiency on producing center dot OH but also consume GSH, which dramatically increases the intracellular oxidative stress in both directions.In vitroexperiments showed that the incubation of human breast cancer cells (MCF-7 cells) with 100 mu g mL(-1)FCB nanoparticles resulted in a 65.9% mortality rate after 24 h. Thein vivoexperiments showed that FCB could effectively inhibit tumor growth. In this study, a therapeutic strategy based on metal biomaterials with good biocompatibility was established to effectively enhance oxidative stress and has great potential in tumor treatment.
机译：有效地，增强细胞内氧化胁迫血糖（中央点OH），其基于FENTON反应和降低谷胱甘肽（GSH）是癌症治疗的有希望的方法。在此，我们合成了一种新的合金纳米材料，Fe5Cu3O @ BSA（FCB），旨在引入铜离子以提高芬顿反应效率并减少GSH。在肿瘤的弱酸微环境下，FCB可以释放Fe（2+）和Cu（2+），并且预期释放的游离电子将与氧气结合以进一步产生H 2 O 2，导致H（2）O的过量产生（2）在细胞中。同时，释放的Fe（2+）和Cu（2+）不仅可以在生产中心点oh进行更高的反应效率，而且还消耗GSH，这显着增加了两个方向上的细胞内氧化应激。在vitropperiment表明孵化表明具有100μgmm（-1）Fcb纳米颗粒的人乳腺癌细胞（MCF-7细胞）导致24小时后的死亡率为65.9％。本发明的实例显示FCB可以有效地抑制肿瘤生长。在该研究中，建立了一种基于金属生物材料的治疗策略，建立了具有良好生物相容性的氧化胁迫，在肿瘤治疗中具有很大的潜力。

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  • 来源
    《New Journal of Chemistry》 |2020年第34期|共9页
  • 作者

    Lv Rongmu; Du Keke; Liu Qianqian; Meng Xiangyu; Chen Lizhu; Wang Zhifei;

  • 作者单位

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

    Southeast Univ Sch Chem &

    Chem Engn Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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