Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time

Ban Yanan; Wang Ruihui; Li Yang; An Zhen; Yu Mingming; Fang Chenjie; Wei Liuhe; Li Zhanxian

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Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time

机译：线粒体靶向比率荧光荧光荧光检测，肼具有快速响应时间

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A ratiometric fluorescent probe 1 was synthesized, which exhibited high sensitivity and excellent selectivity for hydrazine recognition. Probe 1 can quantitatively detect hydrazine in the concentration range from 30 to 180 mu M with a LOD of 2.1 mu M. Furthermore, it displayed excellent selectivity, anti-interference over many nucleophilic species, biological species, metal ions and anions, and a fast response time (4 min). Due to its ability to target mitochondria, the response of hydrazine to this probe in a living cell was successfully tracked in a ratiometric manner via fluorescence imaging.

机译：合成了比例荧光探针1，其表现出高灵敏度和优异的肼识别选择性。探针1可以定量检测浓度范围内的肼范围为2.1μm的浓度范围。此外，它显示出优异的选择性，抗干扰在许多亲核种类，生物物种，金属离子和阴离子上，以及快速的响应时间（4分钟）。由于其靶向线粒体的能力，通过荧光成像成功地跟踪了肼对活细胞中的探针的响应。

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来源
《New Journal of Chemistry》 |2018年第3期|共6页
作者
Ban Yanan; Wang Ruihui; Li Yang; An Zhen; Yu Mingming; Fang Chenjie; Wei Liuhe; Li Zhanxian;
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作者单位

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

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正文语种 eng
中图分类化学;
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1. Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time [J] . Ban Yanan, Wang Ruihui, Li Yang, New Journal of Chemistry . 2018,第3期

机译：线粒体靶向比率荧光荧光荧光检测，肼具有快速响应时间
2. A dual-response ratiometric fluorescent probe for hypochlorite and hydrazine detection and its imaging in living cells [J] . Wang Lin, Pan Qi, Chen Yuan, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2020,第1期

机译：用于次氯酸盐和肼检测的双响应比荧光探针及其活细胞成像
3. A new quinoline-derived highly-sensitive fluorescent probe for the detection, of hydrazine with excellent large-emission-shift ratiometric response [J] . Wu Qingqing, Zheng Jianlu, Zhang Wencui, Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2019,第期

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5. Ratiometric Near-Infrared Fluorescent Probes for the Sensitive Detection of Intracellular pH and Bio-Thiols in Live Cells [D] . Xia, Shuai . 2020

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Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time

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