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首页> 外文期刊>New Journal of Chemistry >Silver(I) complexes with 2-acetylpyridinebenzoyl-hydrazones exhibit antimicrobial effects against yeast and filamentous fungi
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Silver(I) complexes with 2-acetylpyridinebenzoyl-hydrazones exhibit antimicrobial effects against yeast and filamentous fungi

机译：用2-乙酰吡啶苄酰基 - 腙的银（I）配合物表现出对酵母和丝状真菌的抗微生物作用

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Complexes [Ag(H2AcPh)NO3] (1) [Ag(H2AcpCH(3)Ph)NO3] (2) [Ag(H2AcpClPh)NO3] (3) and [Ag(H2AcpNO(2)Ph)NO3] (4) were obtained with 2-acetylpyridinebenzoylhydrazone (H2AcPh) and its para-methyl-(H2AcpCH(3)Ph), parachloro-(H2AcpClPh) and para-nitro-benzoylhydrazone (H2AcpNO(2)Ph) derivatives. In general, upon coordination to silver(I) the antimicrobial activity of the hydrazones increased against yeast and filamentous fungi. Several compounds proved to be as or more active than nystatin against the filamentous fungi. SAR studies showed that, in most of the cases, the antifungal activities against the Candida strains correlate well with the energy of the HOMO orbital, suggesting that an external electrophilic attack to these compounds or an electron donation from these compounds to the targets might be involved in their biochemical pathways. On the other hand, for the Aspergillus and Penicillium strains the antifungal activities of the compounds under study correlate well with logP. Hence, their ability to transpose biological membranes might be responsible for their capacity to reach the target. Taking into consideration the reported resistance to the current antifungal drugs and their adverse side effects, the compounds under study deserve to be further investigated as antimicrobial drug candidates.
机译：复合物[Ag（H2acH）NO3]（1）[Ag（H2AcPCH（3）pH）NO3]（2）[Ag（H2acpclph）NO3]（3）和[Ag（H2AcPNO（2）pH）NO3]（4）用2-乙酰吡啶苄过济酰肼（H2AcPH）及其对 - 甲基 - （H2AcPCH（3）pH），离散甲酰 - （H2acPCLPH）和对硝基 - 苯甲酰基酰肼（H2AcPNO（2）pH）衍生物获得。通常，在与银（I）协调（I）含有氮的抗微生物活性增加酵母和丝状真菌。几种化合物被证明与对丝状真菌的混合物素一样或更活跃。 SAR的研究表明，在大多数情况下，对念珠菌菌株的抗真菌活性与同性恋轨道的能量相比良好，这表明对这些化合物的外部亲电子攻击或从这些化合物到靶标的电子捐赠在他们的生化途径。另一方面，对于Aspergillus和青霉菌菌株，所研究的化合物的抗真菌活性与LOMP相关。因此，他们转让生物膜的能力可能负责其到达目标的能力。考虑到报告的抗性抗真菌药物及其不良副作用，研究中的化合物应得进一步研究为抗微生物药物候选物。

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