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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Restoration of the Topological Organization of the Trigeminal System Following Trigeminal Nerve Root Injury in the Lamprey
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Restoration of the Topological Organization of the Trigeminal System Following Trigeminal Nerve Root Injury in the Lamprey

机译：在李林普雷中三叉神经根损伤后三叉系统的拓扑组织恢复

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摘要

Two issues were examined regarding the trigeminal system in larval lampreys: (1) for normal animals, double labeling was used to confirm that the trigeminal system has a topological organization; (2) following trigeminal nerve root transections, double labeling was used to test whether the topological organization of the trigeminal system is restored. First, for normal animals, Alexa 488 dextran amine applied to the medial oral hood (anterior head) labeled trigeminal motoneurons (MNs) in the ventromedial part of the trigeminal motor nuclei (nVm) and axons of trigeminal sensory neurons (SNs) in the ventromedial part of the trigeminal descending tracts (dV). Also, Texas red dextran amine (TRDA) applied to the lateral oral hood labeled trigeminal MNs in the dorsolateral nVm and sensory axons in the dorsolateral dV. These results confirm the topological organization of the trigeminal system of normal lampreys. Second, following trigeminal nerve root transections, the physical integrity of the nerves was restored during growth of trigeminal sensory and motor axons. In addition, double labeling indicated a restoration and refinement of the topological organization of the trigeminal system with increasing recovery times, but mainly for nVm. Despite the paucity of growth of trigeminal sensory axons in dV even at long recovery times (12-16 wks), a substantial percentage of experimental animals recovered trigeminal-evoked swimming responses and trigeminal-evoked synaptic responses in reticulospinal (RS) neurons. Following trigeminal nerve root injury, several mechanisms, including axonal guidance cues, probably contribute to the substantial restoration of the topological organization of the lamprey trigeminal system. (C) 2019 Published by Elsevier Ltd on behalf of IBRO.
机译：针对幼虫Lampreys的三叉体系进行了两次问题：（1）对于正常动物，使用双标记来证实三叉体系具有拓扑组织; （2）在三叉神经根横断之后，使用双标记来测试三叉系统的拓扑组织是否恢复。首先，对于正常的动物，Alexa 488葡聚糖胺施用于中介口腔罩（前部）标记的三叉子运动神经罩（MNS）在三叉子电机核（NVM）的腹部部分和腹侧三叉肠道感觉神经元（SNS）的轴突中一部分三叉子下降的束（DV）。此外，德克萨斯红葡聚糖胺（TRDA）施加到背侧NVM和背侧DV中的背侧NVM和感觉轴突中的三叉口腔罩。这些结果证实了普通Lampreys三叉系统的拓扑组织。其次，继三叉神经根横断之后，在三叉型感官和电动机轴突的生长期间恢复神经的物理完整性。此外，双重标签表明了三叉体系的拓扑组织的恢复和改进，随着恢复时间的增加，但主要用于NVM。尽管甚至在DV中的三叉体感官轴突的增长，即使在长的恢复时间（12-16周期）中，仍有大量的实验动物恢复了三叉诱发的游泳反应和特征诱发的近视​​（RS）神经元的突触突出反应。在三叉神经根损伤之后，几种机制包括轴突引导提示，可能有助于大规模恢复LAMPREY三叉系统的拓扑组织。 （c）2019年由elsevier有限公司代表银布发布。

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