...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake
【24h】

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

机译：CD36（SR-B2）的翻译后修饰：对调节肌细胞脂肪酸摄取的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The membrane-associated protein CD36, now officially designated as SR-B2, is present in various tissues and fulfills multiple cellular functions. In heart and muscle, CD36 is the main (long-chain) fatty acid transporter, regulating myocellular fatty acid uptake via its vesicle-mediated reversible trafficking (recycling) between intracellular membrane compartments and the cell surface. CD36 is subject to various types of post-translational modification. This review focusses on the role of these modifications in further regulation of myocellular fatty acid uptake. Glycosylation, ubiquitination and palmitoylation are involved in regulating CD36 stability, while phosphorylation at extracellular sites affect the rate of fatty acid uptake. In addition, CD36 modification by O-linked N-acetylglucosamine may regulate the translocation of CD36 from endosomes to the cell surface. Acetylation of CD36 has also been reported, but possible effects on CD36 expression and/or functioning have not yet been addressed. Taken together, CD36 is subject to a multitude of post-translational modifications of which their functional implications are beginning to be understood. Moreover, further investigations are needed to disclose whether these post-translational modifications play a role in altered fatty acid uptake rates seen in several pathologies of heart and muscle. This article is part of a special issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck and Jan F.C. Glatz. (C) 2016 Elsevier B.V. All rights reserved.
机译：膜相关蛋白CD36（现正式命名为SR-B2）存在于各种组织中，并具有多种细胞功能。在心脏和肌肉中，CD36是主要的（长链）脂肪酸转运蛋白，通过其在细胞内膜区室和细胞表面之间的小泡介导的可逆转运（再循环）来调节肌细胞脂肪酸的摄取。 CD36会进行各种类型的翻译后修饰。这篇综述集中于这些修饰在进一步调节肌细胞脂肪酸摄取中的作用。糖基化，泛素化和棕榈酰化参与调节CD36的稳定性，而细胞外位点的磷酸化则影响脂肪酸的摄取速率。另外，通过O-连接的N-乙酰氨基葡糖胺进行的CD36修饰可以调节CD36从内体到细胞表面的转运。也已经报道了CD36的乙酰化，但是尚未解决对CD36表达和/或功能的可能影响。综上所述，CD36受到多种翻译后修饰的修饰，其功能含义已开始被理解。而且，需要进一步的研究来揭示这些翻译后修饰是否在心脏和肌肉的几种病理学中观察到的脂肪酸摄取率改变中起作用。本文是特刊（Jason R.B. Dyck和Jan F.C.编辑）的特刊的一部分：翻译后蛋白质修饰对心脏和血管代谢的作用。格拉茨（C）2016 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号