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TLRs in pulmonary diseases

机译：肺病中的TLRS

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摘要

Toll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering a suitable response against pathogenic attacks. As lung is steadily exposed to multiple infectious agents, antigens and host-derived danger signals, the inhabiting stromal and myeloid cells of the lung express an aggregate of TLRs which perceive the endogenously derived damage-associated molecular patterns (DAMPs) along with pathogen associated molecular patterns (PAMPs) and trigger the TLR-associated signalling events involved in host defence. Thus, they form an imperative component of host defence activation in case of microbial infections as well as noninfectious pulmonary disorders such as interstitial lung disease, acute lung injury and airways disease, such as COPD and asthma. They also play an equally important role in lung cancer. Targeting the TLR signalling network would pave ways to the design of more reliable and effective vaccines against infectious agents and control deadly infections, desensitize allergens and reduce inflammation. Moreover, TLR agonists may act as adjuvants by increasing the efficiency of cancer vaccines, thereby contributing their role in treatment of lung cancer too. Overall, TLRs present a compelling and expeditiously bolstered area of research and addressing their signalling events would be of significant use in pulmonary diseases.
机译：Toll样受体（TLR）包含蛋白质的氏族，参与鉴定并触发适当的抗癌致病症。由于肺部稳定地暴露于多种传染病，抗原和宿主衍生的危险信号，肺部的基质和髓样细胞表达TLR的聚集体，其感知内源性衍生的损伤相关分子模式（潮湿）以及相关的分子的病原体模式（PAMP）并触发主机防御所涉及的TLR相关的信令事件。因此，在微生物感染的情况下，它们形成了宿主防毒活化的势在必行组分，以及非血液性肺病，急性肺损伤和空气道疾病，如COPD和哮喘。它们也在肺癌中发挥同样重要的作用。瞄准TLR信令网络将对传染病的更可靠和有效的疫苗设计，并控制致命感染，脱敏过敏原并减少炎症。此外，TLR激动剂可以通过提高癌症疫苗的效率作为佐剂，从而有助于它们在治疗肺癌中的作用。总体而言，TLRS展示了一个引人注目的，迅速的研究领域的研究和解决他们的信令事件对于肺病具有重要用途。

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