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首页> 外文期刊>Life sciences >Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
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Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

机译：槲皮素在衰减阿尔茨海默病中的保护作用潜在的保护作用

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摘要

Quercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmonary, schizophrenia and cardiovascular diseases. Quercetin possesses scavenging potential of hydroxyl radical (OH-), hydrogen peroxide (H2O2), and superoxide anion (O-2(-)). These reactive oxygen species (ROS) hampers lipid, protein, amino acids and deoxyribonucleic acid (DNA) processing leading to epigenetic alterations. Quercetin has the ability to combat these harmful effects. ROS plays a vital role in the progression of Alzheimer's disease (AD), and we propose that quercetin would be the best choice to overcome cellular and molecular signals in regulating normal physiological functions. However, data are not well documented regarding exact cellular mechanisms of quercetin. The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways. Therefore, the aim of the present review was to elaborate on the cellular and molecular mechanisms of the quercetin involved in the protection against AD.
机译：槲皮素属于黄酮类动物，这些家庭存在于大多数植物中，包括水果，蔬菜，绿茶，甚至在具有抗氧化活性的红葡萄酒中。它可作为市场上的食品补充剂，具有生理健康影响。槲皮素具有抗炎，抗癌和抗前列腺活动，以及其对高胆固醇，肾移植，哮喘，糖尿病，病毒感染，肺癌，精神分裂症和心血管疾病的有益作用。槲皮素具有清除羟基自由基（OH-），过氧化氢（H 2 O 2）和超氧化物阴离子（O-2（ - ））的清除潜力。这些反应性氧（ROS）湿润，蛋白质，氨基酸和脱氧核糖核酸（DNA）加工，导致表观遗传改变。槲皮素具有打击这些有害影响的能力。 ROS在阿尔茨海默病（AD）的进展中起着至关重要的作用，我们提出槲皮素是克服调节正常生理功能时细胞和分子信号的最佳选择。然而，关于槲皮素的确切细胞机制并不充分记录数据。槲皮素的神经保护作用主要是由于核因子（红细胞衍生2） - 酮2（NRF2），律氧基酶-2，C-6月N-末端激酶（JNK）的核因子上和/或下调细胞因子的潜在和/或下调，蛋白激酶C，丝裂原激活蛋白激酶（MAPK）信号级联，以及PI3K / AKT途径。因此，本综述的目的是详细阐述槲皮素的细胞和分子机制参与保护免受广告。

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