Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

Shi Qianqian; Chen Xiuying; Sun Guangli; Wang Lili; Cui Longjiang

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Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

机译：人参皂甙RG1通过MIR-26a的上调保护人的视网膜色素上皮ARPERIAL-19细胞免受高葡萄糖的毒性

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Aims: The therapeutic strategies for diabetic retinopathy (DR) are disappointing. Ginsenoside Rg1 (Rg1) extracted from Panax ginseng can induce glucose uptake and lower oxidative stress. We aimed to explore the effect of Rg1 on DR using human retinal pigment epithelium cells (ARPE-19).

机译：目的：糖尿病视网膜病变（DR）的治疗策略令人失望。从Panax人参中提取的人参皂苷RG1（RG1）可以诱导葡萄糖摄取和较低的氧化应激。我们旨在使用人视网膜颜料上皮细胞（ARPE-19）探讨RG1对DR的影响。

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来源
《Life sciences》 |2019年第2019期|共7页
作者
Shi Qianqian; Chen Xiuying; Sun Guangli; Wang Lili; Cui Longjiang;
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作者单位

Henan Prov Peoples Hosp Henan Eye Hosp Henan Eye Inst Dept Ophthalmol 7 Weiwu Rd Zhengzhou;

Zhengzhou Univ Sch Pharmaceut Sci Coinnovat Ctr Henan Prov New Drug R&

D &

Preclin S Key Lab Adv;

Zhengzhou Univ Affiliated Hosp 1 Dept Ophthalmol Zhengzhou 450000 Henan Peoples R China;

Peoples Hosp Zhengzhou Dept Ophthalmol Zhengzhou 450000 Henan Peoples R China;

Henan Prov Peoples Hosp Henan Eye Hosp Henan Eye Inst Dept Ophthalmol 7 Weiwu Rd Zhengzhou;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Diabetic retinopathy; High glucose; Ginsenoside Rg1; microRNA-26a; ERK/Wnt/beta-catenin;

机译：糖尿病视网膜病;高葡萄糖;人参皂苷Rg1;microRNA-26a;ERK / WNT / BETA-CAT键;

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专利

1. Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a [J] . Shi Qianqian, Chen Xiuying, Sun Guangli, Life sciences . 2019,第期

机译：人参皂甙RG1通过MIR-26a的上调保护人的视网膜色素上皮ARPERIAL-19细胞免受高葡萄糖的毒性
2. Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells [J] . Chang Yo-Chen, Hsieh Ming-Chu, Wu Horng-Jiun, Toxicology in vitro: an international journal published in association with BIBRA . 2015,第7期

机译：甲基乙二醛，一种反应性葡萄糖代谢产物，增强自噬通量并抑制人视网膜色素上皮ARPE-19细胞的增殖
3. Toxicity and phototoxicity in human ARPE-19 retinal pigment epithelium cells of dyes commonly used in retinal surgery [J] . Awad Doaa, Wilinska Joanna, Gousia Dimitra, European journal of ophthalmology . 2018,第4期

机译：常用于视网膜手术的人ArPe-19视网膜色素上皮细胞中的毒性和光毒性
4. Quantitative pigment extraction analysis for human pluripotent stem cell derived retinal pigment epithelial cells [C] . J. Rieck, K. Juuti-Uusitalo, R. Autio European Medical Biological Engineering Conference . 2018

机译：人多能干细胞衍生视网膜色素上皮细胞的定量颜料提取分析
5. Ginseng pharmacology: Signaling pathways of ginsenoside -Rg1 in human umbilical vein endothelial cells [D] . Leung, Kar Wah 2006

机译：人参药理学：人参皂苷-Rg1在人脐静脉内皮细胞中的信号传导途径
6. Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145 [O] . Yi Dong, Cheng Qian, Guangming Wan, 2020

机译：五味子素A通过调节miR-145保护人类视网膜色素上皮细胞系ARPE-19免受HG诱导的细胞损伤
7. Green Tea epigallocatechin-3-gallate Protects Against Oxidative Stress-Induced Nuclear Translocation of p53 and Apoptosis in Retinal Pigment Epithelial Cells, ARPE-19 [O] . Kanokpan Wongprasert, Yindee Kitiyanant, Kornnika Khanobdee, 2013

机译：绿茶epigallocatechin-3-gallate可防止氧化应激诱导的p53核易位和视网膜色素上皮细胞凋亡，ARPE-19。

Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

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