Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

Cinar Irfan; Sirin Busra; Aydin Pelin; Toktay Erdem; Cadirci Elif; Halici Iclal; Halici Zekai

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Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

机译：Gosypin对大鼠实验脓毒症模型中急性肺损伤的改善作用

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Aims: Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs.

机译：目的：败血症是一种复杂的病理生理事件，涉及全身炎症反应综合征，多器官功能障碍综合征和组织损伤，如急性肺损伤（ALI）。虽然正在研究许多新机制以启发败血症的病理生理学，但尚无有效的治疗方案。已经显示了抗氧化剂，抗污染和抗炎作用的抗氧化剂，抗菌和抗炎作用，并且我们假设GOS在败血症诱导肺部炎症中具有作用。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Cinar Irfan; Sirin Busra; Aydin Pelin; Toktay Erdem; Cadirci Elif; Halici Iclal; Halici Zekai;
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作者单位

Kafkas Univ Dept Pharmacol Fac Med Kars Turkey;

Ataturk Univ Dept Pharmacol Fac Med TR-25240 Erzurum Turkey;

Erzurum Reg Training &

Res Hosp Dept Anesthesiol &

Reanimat Erzurum Turkey;

Ataturk Univ Dept Histol &

Embriol Fac Med TR-25240 Erzurum Turkey;

Ataturk Univ Dept Pharmacol Fac Med TR-25240 Erzurum Turkey;

Ataturk Univ Fac Med Infect Community TR-25240 Erzurum Turkey;

Ataturk Univ Dept Pharmacol Fac Med TR-25240 Erzurum Turkey;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
CLP; Lung injury; Gossypin; NLRP3; HMG beta 1; NF-kappa B;

机译：CLP;肺损伤;Gossypin;NLRP3;HMG BETA 1;NF-KAPPA B;

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专利

1. Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats [J] . Cinar Irfan, Sirin Busra, Aydin Pelin, Life sciences . 2019,第期

机译：Gosypin对大鼠实验脓毒症模型中急性肺损伤的改善作用
2. Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1 [J] . Matsuishi Yujiro, Jesmin Subrina, Kawano Satoru, Life sciences . 2016,第Null期

机译：盐酸兰地洛尔通过抑制肺内皮素-1水平的升高改善了早期败血症大鼠的急性肺损伤
3. L-lysine ameliorates sepsis-induced acute lung injury in a lipopolysaccharide-induced mouse model [J] . Zhang Yang, Wu Yu, Han Dong, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第118期

机译：L-赖氨酸在脂多糖诱导的小鼠模型中改善败血症诱导的急性肺损伤
4. The experimental study on the interventional effect of Chinese herb 912 liquor on the rat model with acute lung injury [C] . WANG Ying, ZHANG Shu-wen, WANG Bao-en National Young Scientist's Symposium on Integrative Medicine . 2002

机译：中药912液干预大鼠急性肺损伤模型的实验研究。
5. Cell- and cell-based gene therapy for experimental acute lung injury and sepsis. [D] . Mei, Shirley Hsin-Ju. 2008

机译：基于细胞和细胞的基因治疗实验性急性肺损伤和败血症。
6. Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury [O] . Wei Fan, Koichi Nakazawa, Shinya Abe, 2013

机译：在急性肺损伤的实验模型中吸入雾化的胰岛素可改善高血糖引起的肺部炎症反应
7. Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1 [O] . Matsuishi Yujiro, Jesmin Subrina, Kawano Satoru, 2016

机译：盐酸兰地洛尔通过抑制升高的肺内皮素-1水平改善早期脓毒症大鼠的急性肺损伤
8. Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury [R] . Roman, J. 2006

机译：脓毒症致急性肺损伤组织重塑机制的研究

Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

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