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首页> 外文期刊>Life sciences >Protective effect of a polyphenols-rich extract from Inonotus Sanghuang on bleomycin-induced acute lung injury in mice
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Protective effect of a polyphenols-rich extract from Inonotus Sanghuang on bleomycin-induced acute lung injury in mice

机译：富含酚中含有柚子的保护作用Sanghuang对小鼠抗霉素诱导的急性肺损伤

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摘要

Mushroom Phellinus linteus ("Sanghuang" in Chinese) is a popular medicinal polypore used to treat several disorders through its various biological functions. Inonotus sanghuang is claimed to produce general immune-potentiating and strengthening, anti-inflammatory, anti-tumor and anti-microbial properties, but its effect on acute lung inflammation and oxidative stress are not clearly understood. To determine the effect and mechanism of the polyphenols-rich ethyl acetate fraction from wild I. sanghuang extract (ISE) on acute lung injury (ALI) induced by bleomycin (BLM), female C57BL/6 mice were fed ISE (0%, 0.15% or 0.6% in diet) for 4 weeks prior to challenge with BLM. Bronchoalveolar lavage fluid (BALF) from lung, spleen and lung tissues were collected on day 3 after BLM challenge for histological, oxidative stress, molecular and biochemical analysis. ISE supplementation improved pathological features in lung injury scores and reduced lung wet-to-dry ratios. Moreover, ISE reduced inflammatory cell infiltration and the pro-inflammatory cytokines including IL-1 beta, IL-6 and TNF-alpha in BALF, decreased the MPO activity and the MDA level and increased the SOD, CAT and GSH-Px activities in lung tissue homogenates. Further mechanism analysis demonstrated that dietary ISE inhibited NF-KB signal. Finally, peripheral immune function analysis showed that ISE had less effect on immune response including splenocyte producing inflammatory cytokines and T cell proliferation except for IL-1 beta and IL-2. Our findings indicate the possibility that dietary ISE attenuates ALI induced by BLM through correcting the inflammation and oxidation balance at least in part via inhibiting NF-kappa B signal in vivo, suggesting that ISE might be a valuable medicinal food effective in improving lung injury.
机译：Mushroom phellinus Linteus（“僧人”中文）是一种受欢迎的药用息肉，用于通过各种生物功能治疗几种疾病。声称僧人僧人制作一般免疫增强，抗炎，抗肿瘤和抗微生物性质，但其对急性肺炎和氧化应激的影响不明白。为了确定野生I.富苯酚富乙酸乙酯级分的效果和机制来自野生I.冬季菌（BLM）诱导的急性肺损伤（ALI），雌性C57BL / 6小鼠喂养ISE（0％，0.15饮食中的％或0.6％）在攻击BLM之前4周。在BLM挑战后第3天收集来自肺，脾脏和肺组织的支气管肺泡血液（BALF），用于组织学，氧化应激，分子和生化分析。 ISE补充改善了肺损伤分数的病理特征，降低了肺部湿对干比。此外，ISE降低了炎性细胞浸润和BALF中包括IL-1β，IL-6和TNF-α的促炎细胞因子，降低了MPO活性和MDA水平，并增加了肺中的SOD，猫和GSH-PX活性组织匀浆。进一步的机制分析证明膳食ISE抑制NF-KB信号。最后，外周免疫功能分析表明，ISE对免疫应答的影响较小，包括产生炎症细胞因子和T细胞增殖的脾细胞，除IL-1β和IL-2之外。我们的研究结果表明，膳食ISE通过抑制体内NF-Kappa B信号至少部分地通过校正炎症和氧化平衡，饮食ISE通过校正炎症和氧化平衡而衰减，表明ISE可能是有效改善肺损伤的有效药用食品。

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  • 来源
    《Life sciences》 |2019年第2019期|共10页
  • 作者

    Su Xing; Liu Kun; Xie Yu; Zhang Mengdi; Wang Yong; Zhao Min; Guo Yilin; Zhang Yijie; Wang Junpeng;

  • 作者单位

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Hebei Univ Econ &

    Business Coll Biol Sci &

    Engn Shijiazhuang 050061 Hebei Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Henan Univ Pathol Huaihe Hosp Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Inst Infect &

    Immun Kaifeng 475000 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Inonotus sanghuang polyphenols; Inflammation; Oxidative stress; Acute lung injury; NF-kappa B signal;

    机译：Inonotus sanghuang多酚;炎症;氧化应激;急性肺损伤;NF-Kappa B信号;

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