Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway

Li Qi; An Xinglan; Man Xiaxia; Chu Meiran; Zhao Tianchuang; Yu Hao; Li Ziyi

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Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway

机译：转录组分析表明，环磷酰胺通过阻断胆固醇生物合成途径诱导过早的卵巢衰竭

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Aims: The present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.

机译：目的：本研究旨在通过转录组分析研究小鼠过早卵巢衰竭（POF）的环磷酰胺（Cytoxan，CTX）的影响及其调节机制。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Li Qi; An Xinglan; Man Xiaxia; Chu Meiran; Zhao Tianchuang; Yu Hao; Li Ziyi;
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作者单位

Jilin Univ Hosp 1 Minist Educ Key Lab Organ Regenerat &

Transplantat Changchun 130021 Jilin;

Jilin Univ Hosp 1 Minist Educ Key Lab Organ Regenerat &

Transplantat Changchun 130021 Jilin;

Jilin Univ Hosp 1 Minist Educ Key Lab Organ Regenerat &

Transplantat Changchun 130021 Jilin;

Jilin Univ Coll Vet Med Changchun 130062 Jilin Peoples R China;

Jilin Univ Coll Vet Med Changchun 130062 Jilin Peoples R China;

Jilin Univ Coll Anim Sci Changchun 130062 Jilin Peoples R China;

Jilin Univ Hosp 1 Minist Educ Key Lab Organ Regenerat &

Transplantat Changchun 130021 Jilin;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
CTX; POF; RNA-seq; Mice; Transcriptome;

机译：CTX：POF;RNA-SEQ;小鼠;转录组;

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1. Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway [J] . Li Qi, An Xinglan, Man Xiaxia, Life sciences . 2019,第期

机译：转录组分析表明，环磷酰胺通过阻断胆固醇生物合成途径诱导过早的卵巢衰竭
2. Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway [J] . Ying Xiong, Te Liu, Suwei Wang, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2016,第期

机译：环磷酰胺通过激活LNCRNA-MEG3-P53-P66SHC途径促进小鼠卵巢颗粒细胞的增殖抑制和过早的卵巢衰竭
3. Oral Cyclophosphamide Confounds the Relationship between CYP2C19 and CYP2B6 Pharmacogenetics and Cyclophosphamide-induced premature Ovarian Failure in Lupus Nephritis Patients [J] . Nuala Helsby, Michael Goldthorpe, Peter Gow, Advances in Pharmacology and Pharmacy . 2013,第1期

机译：口服环磷酰胺混淆了狼疮性肾炎患者中CYP2C19和CYP2B6的药物遗传学和环磷酰胺诱发的卵巢早衰之间的关系
4. Anti-TNF -a treatment-related pathways and biomarkers revealed by transcriptome analysis in Chinese psoriasis patients [C] . Asia Pacific Bioinformatics Conference . 2019

机译：抗TNF -A治疗相关的途径和生物标志物，在中国牛皮癣患者转录组分析显示
5. Characterization of residual ovarian tissue in mice following 4-vinylcyclohexene diepoxide-induced ovarian failure. [D] . Craig, Zelieann Rivera. 2009

机译：4-乙烯基环己烯二环氧化合物诱导的卵巢衰竭后小鼠体内残留卵巢组织的特征。
6. Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis [O] . Cai-rong Zhang, Wei-na Zhu, Wei Tao, 2021

机译：通过抑制NLRP3- / caspase-1- / GSDMD依赖性辐注艾灸抗环磷酰胺诱导的大鼠过早的卵巢衰竭
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Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway

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