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首页> 外文期刊>Life sciences >Strain differences in the distribution of N-methyl-d-aspartate and gamma (gamma)-aminobutyric acid-A receptors in rat brain.
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Strain differences in the distribution of N-methyl-d-aspartate and gamma (gamma)-aminobutyric acid-A receptors in rat brain.

机译：菌株差异差异在大鼠脑中N-甲基-D-天冬氨酸和γ（γ） - 氨基丁酸 - 大鼠脑中受体的差异。

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AIMS: Previous studies have shown that the Wistar-Kyoto (WKY) rat strain exhibits depressive symptoms such as anhedonia, psychomotor retardation, ambivalence and negative memory bias following exposure to stress. Given the involvement of excitatory glutamate and inhibitory gamma (gamma)-aminobutyric acid (GABA) signaling pathways in influencing depressive behavior, the present study investigated strain differences in the distribution of central N-methyl-d-aspartate (NMDA) and GABA(A) receptor sites in WKY compared to their inbred counterpart, Wistar (WIS) rats. MAIN METHODS: Quantitative autoradiographic analysis was used to map the binding and distribution of NMDA and GABA(A) receptors in various brain regions in WKY and WIS rats. KEY FINDINGS: Results indicated a significant difference between the two strains. Lower NMDA receptor binding was found in the anterior cingulate cortex, caudate putmen, nucleus accumbens, CA1 region of the hippocampus and the substantia nigra pars reticulata in WKY compared to WIS rats. Conversely, higher GABA(A) receptor binding was found in the amygdala, caudate putmen, dentate gyrus, CA2 and CA3 fields of the hippocampus, periaqueductal grey and substantia nigra pars reticulata in WKY compared to WIS rats. SIGNIFICANCE: Given that these two rat strains differ in their behavioural, endocrine and neurochemical profile, the observed strain differences in NMDA and GABA(A) receptor binding suggest that these two neurotransmitter systems may be involved in the depressive and stress-sensitive phenotype of the WKY rat strain.
机译：AIMS：先前的研究已经表明，只Wistar-京都（WKY）大鼠品系表现出抑郁症状如快感缺乏，精神运动迟缓，并且矛盾在暴露于应力负存储器偏压。鉴于兴奋性谷氨酸和抑制伽马（伽马）氨基丁酸（GABA）在影响抑郁行为信号传导途径的参与，本研究调查了中央N-甲基d天冬氨酸（NMDA）和GABA的分布应变差异（A ）相比，他们的近亲配对的WKY受体位点，只Wistar（WIS）的大鼠。主要方法：放射自显影定量分析用于映射NMDA和GABA（A）受体在不同脑区域中WKY结合和分布和WIS大鼠。主要发现：结果表明两种菌株之间的差异显著。下NMDA受体结合用的前扣带皮层，尾状putmen，伏核，CA1区海马，发现黑质网状相比WIS大鼠WKY。相反，较高的GABA（A）受体结合在杏仁核，尾状putmen，齿状脑回发现，海马CA2和CA3字段，导水管周围灰质和黑质网状相比WIS大鼠WKY。意义：鉴于这两种大鼠品系在他们的行为，内分泌和神经化学特征不同，在NMDA和GABA所观察到的应变差异（A）受体结合表明，这两种神经递质系统可以在的抑郁和应力敏感表型参与WKY大鼠品系。

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