The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism.

Furlan AJ; Abou Chebi A

首页> 外文期刊>Current medical research and opinion >The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism.

【24h】

The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism.

机译：重组尿激酶原（r-pro-UK）和动脉内溶栓在急性缺血性卒中中的作用：PROACT试验。急性脑血栓栓塞症。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

By delivering a higher concentration of drug directly into a clot, intra-arterial (IA) thrombolysis may be more effective than intravenous therapy at opening a blocked artery. The clinical efficacy and safety of IA thrombolysis with the selective thrombolytic r-pro-urokinase (r-pro-UK) has been demonstrated in two randomized acute stroke treatment trials, PROACT I and PROACT II. However, IA pro-UK is not yet FDA approved, and it is not known if IA thrombolysis with other agents would have the same results. However the American Heart Association has deemed IA thrombolysis an 'acceptable alternative therapy' and many stroke centres are offering it to patients with a major acute stroke presenting within 6 h.

机译：通过直接将较高浓度的药物直接递送到血凝块中，动脉内（IA）溶栓可能比静脉内治疗更有效地打开阻塞的动脉。选择性随机溶栓性r-尿激酶原（r-pro-UK）对IA溶栓的临床疗效和安全性已在两项随机急性卒中治疗试验PROACT I和PROACT II中得到证实。但是，IA pro-UK尚未获得FDA的批准，也不清楚IA与其他药物的溶栓效果是否相同。但是，美国心脏协会将IA溶栓治疗视为“可接受的替代疗法”，许多中风中心正在为6小时内出现严重急性中风的患者提供溶栓治疗。

著录项

来源
《Current medical research and opinion》 |2002年第2期|共4页
作者
Furlan AJ; Abou Chebi A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类临床医学;
关键词
saruplase; Thrombolysis; NOS; Acute; Cerebrovascular accident; Intra-Arterial Infusions;

机译：saruplase;血栓溶解;NOS;急性;脑血管意外;动脉内输注;

相似文献

外文文献
中文文献
专利

1. The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism. [J] . Furlan AJ, Abou Chebi A Current medical research and opinion . 2002,第Suppla2期

机译：重组尿激酶原（r-pro-UK）和动脉内溶栓在急性缺血性卒中中的作用：PROACT试验。急性脑血栓栓塞症。
2. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism (see comment) [J] . Furlan A, Higashida R, Wechsler L, JAMA: the Journal of the American Medical Association . 1999,第21期

机译：动脉内尿激酶用于急性缺血性中风。 PROACT II研究：一项随机对照试验。急性脑血栓栓塞症（见评论）
3. Computed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trial. [J] . Roberts HC, Dillon WP, Furlan AJ, Stroke: A Journal of Cerebral Circulation . 2002,第6期

机译：因脑中动脉闭塞而导致的急性缺血性卒中的患者进行动脉内溶栓治疗的计算机断层扫描结果：PROACT II试验的结果。
4. Comparison of classification methods for voxel-based prediction of acute ischemic stroke outcome following intra-arterial intervention [C] . Anthony J. Winder, Susanne Siemonsen, Fabian Flottman, Conference on Computer-Aided Diagnosis . 2017

机译：血管内干预后基于体素的急性缺血性卒中预后分类方法的比较
5. The role of iron-induced oxidative stress in acute ischemic stroke and the potential role for fasciculations in their therapy. [D] . Mehta, Shyamal H. 2003

机译：铁诱导的氧化应激在急性缺血性卒中中的作用以及絮凝剂在其治疗中的潜在作用。
6. Intra-arterial thrombolysis in acute ischaemic stroke: experience with a superselective catheter embedded in the clot. [O] . L Casto, L Caverni, M Camerlingo, 1996

机译：急性缺血性卒中的动脉内溶栓治疗：在血凝块中嵌入超选择性导管的经验。
7. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. [O] . Hill, MD, Rowley, HA, Adler, F, 2003

机译：通过ASPECTS选择尿激酶原对急性缺血性中风患者进行动脉内溶栓治疗。

The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism.

摘要

著录项

相似文献

相关主题

期刊订阅