...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway
【24h】

Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway

机译：Evodiamine通过Hippo-Yes相关的蛋白信号通路抑制增殖并促进肝细胞癌细胞的凋亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims: Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signaling have yet to be ascertained. Here, the effects of Evo on cell proliferation and apoptosis were evaluated using HCC cell lines (HepG2 and Bel-7402) and nude mice with xenograft tumors. We further investigated whether Evo exerts anti-HCC activity through effects on Hippo-YAP signaling in vitro with the aid of XMU-MP-1, an inhibitor of the key component of this pathway, mammalian sterile 20-like kinase 1/2.
机译：目的：已知河马 - 是相关蛋白（YAP）信号通路的功能障碍与肝细胞癌（HCC）相关。 Evodiamine（EVO）是一种植物衍生的生物活性生物碱，对癌症产生抑制作用。 然而，EVO对HCC的确切影响及其对HIPPO-YAP信号传导的潜在效果尚未确定。 这里，使用HCC细胞系（HepG2和Bel-7402）和裸鼠用异种移植肿瘤进行评估EVO对细胞增殖和细胞凋亡的影响。 我们进一步研究了EVO是否借助于XMU-MP-1，通过XMU-MP-1，该途径的关键组分的抑制剂，哺乳动物无菌20样激酶1/2通过对Hippo-Yap信号传导的影响来施用抗HCC活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号