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首页> 外文期刊>Life sciences >Nongenomic and genomic effects of 1alpha,25(OH)2 vitamin D3 in rat testis.
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Nongenomic and genomic effects of 1alpha,25(OH)2 vitamin D3 in rat testis.

机译：大鼠睾丸中1Alpha，25（OH）2维生素D3的组分和基因组作用。

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摘要

The steroid hormone 1alpha,25(OH)(2)-vitamin D(3) (1,25D(3)) regulates gene transcription through a nuclear receptor (VDRnuc) and initiation of rapid cellular responses through a putative plasma membrane-associated receptor (VDRmem). It has been described that successful mating and fertility rates are significantly decreased in vitamin D deficient male rats and a VDR null mutant rodent has decreased sperm count and motility and expresses rare spermatogenesis. Although the Sertoli cells are pointed as the major target of 1,25D(3) in the testis the mechanism of 1,25D(3) action, particularly in Sertoli cells, remains unclear. Several studies undertaken in the testicular cells showed that 1,25D(3) can produce both genomic and nongenotropic actions in those cells. 1,25D(3) can modulate kinase activities and ionic fluxes (Ca(2+) and Cl(-)) at the plasma membrane resulting in the regulation of secretory processes in Sertoli cells. The enormous complexity of the nongenomic actions of 1,25D(3) implies that specific receptor or specific ligand-binding sites located on the plasma membrane or in the nucleus are believed to initiate specific cell responses. Apparently the choice of the signaling pathways to be activated after the interaction of the hormone with cell surface receptors is directly related with the physiological action to be better accomplished. The demonstration that 1,25D(3) can regulate both Sertoli cell and sperm function may be useful for the study and development of new therapeutic strategies to the treatment of male reproductive disorders. This review summarizes recent research on the rapid actions of 1,25D(3) and identifies questions that remain to be answered in this area.
机译：类固醇激素1Alpha，25（OH）（2） - vitamin d（3）（1,25d（3））通过核受体（Vdrnuc）调节基因转录，并​​通过推定的血浆膜相关受体引发快速细胞反应（vdrmem）。已经描述了维生素D缺乏血小大鼠的成功交配和生育率显着降低，并且VDR空突变体啮齿动物具有降低的精子计数和运动，表达稀有的精子发生。尽管睾丸细胞指向1,25d（3）的主要靶标，但在睾丸中的1,25d（3）（3）作用，特别是在Sertoli细胞中的机制仍然不清楚。在睾丸细胞中进行的几项研究表明，1,25d（3）可以在这些细胞中产生基因组和非肝癌作用。 1,25d（3）可以调节在血浆膜上的激酶活性和离子丝网（Ca（2+）和Cl（ - ）），从而导致Sertoli细胞中的分泌过程调节。 1,25d（3）的Nongenomic作用的巨大复杂性意味着位于质膜或核上的特异性受体或特异性配体结合位点被认为引发特异性细胞应答。显然在激素与细胞表面受体的相互作用后，可以选择要激活的信号通路与细胞表面受体的相互作用直接相关，与生理作用更好地完成。 1,25d（3）可以调节Sertoli细胞和精子功能的证明可用于研究和开发新的治疗术治疗男性生殖障碍的策略。本综述总结了最近对1,25d（3）的快速行动的研究，并确定了在该地区仍有待回答的问题。

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